山茱萸叶提取物对四氧嘧啶诱导的糖尿病大鼠胰岛的保护作用和血糖控制作用

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Y. Djabir, H. Hardi, Hesty Setiawati, Subehan Lallo, R. Yulianty, M. Cangara, V. Hadju
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引用次数: 2

摘要

山茱萸叶提取物的抗氧化能力可能对应激氧化诱导的胰腺细胞损伤具有保护作用。本研究旨在探讨鹿角树叶提取物对四氧嘧啶诱导的糖尿病大鼠胰岛结构、血糖和胰岛素水平的影响。大鼠腹腔注射四氧嘧啶(155 mg/kg)诱导糖尿病。每天测量大鼠的BG水平。只有BG值为250 mg/dL的大鼠(n = 25)接受不同的治疗:安慰剂、100、200或400 mg/kg的鹿角树叶提取物或6 IU/200g的胰岛素。在收集血液和胰腺组织样本之前,每天给药14天。选取健康大鼠5只(n = 5)作为正常对照。结果表明,四氧嘧啶诱导的胰岛萎缩和给药均能减轻胰岛萎缩的严重程度。然而,仅在400 mg/kg剂量下,荆芥叶提取物显著降低了大鼠的BG水平(P < 0.05),与胰岛素处理的大鼠相似。与安慰剂治疗相比,芦笋叶提取物(尤其是100和400 mg/kg)也能提高血清胰岛素水平(P < 0.05)。由此可见,荆芥叶提取物具有保护大鼠胰岛免受四氧嘧啶损伤的作用。这种保护作用可以改善大鼠的血糖和胰岛素水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Artocarpus altilis leaf extract protects pancreatic islets and improves glycemic control in alloxan-induced diabetic rats
The antioxidant capacity of Artocarpus altilis leaf extract may offer protection against stress oxidative-induced damage to pancreatic cells. This study aimed to examine the effect of Artocarpus leaf extract on pancreatic islets structure, blood glucose (BG), and insulin serum levels in alloxan-induced diabetic rats. Diabetes mellitus was induced in rats with an intraperitoneal injection of alloxan (155 mg/kg). Rats’ BG levels were measured daily. Only rats with BG >250 mg/dL (n = 25) proceeded to receive different treatments: placebo, Artocarpus leaf extract at the dose of 100, 200, or 400 mg/kg, or insulin 6 IU/200g. All treatments were administered daily for 14 days before blood and pancreatic tissue samples were collected. Five healthy rats (n = 5) were included to serve as normal controls. The result shows that alloxan-induced atrophy of pancreatic islets and Artocarpus leaf extract administration at all given doses reduced the severity of pancreatic islet’s atrophy. However, only at 400 mg/kg dose, Artocarpus leaf extract significantly reduced rats’ BG level (P < 0.05), similar to that of insulin-treated rats. Artocarpus leaf extract, especially at 100 and 400 mg/kg doses, also improved insulin serum levels compared with placebo treatment (P < 0.05). In conclusion, Artocarpus leaf extract protected rats’ pancreatic islets against alloxan-induced damage. This protection could improve the BG and insulin serum levels in Artocarpus-treated rats.
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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