瘤内结核菌素纯化蛋白衍生物治疗掌足底疣安全性和有效性的前瞻性临床研究

Aditi Mishra, S. Shrestha, Shekhar K.C., D. Karn
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引用次数: 1

摘要

背景:疣有多种治疗方案,但没有一种是完全有效的。常规疗法如水杨酸、冷冻疗法的治疗效果不一致。在最近的研究中,免疫疗法、博莱霉素和激光等较新的治疗方式显示出更高的疣清除率。免疫疗法是一种治疗疣的创新方法,它依赖于增强细胞介导免疫的原理。本研究旨在评估结核菌素纯化蛋白衍生物注射免疫治疗掌足底疣的疗效。材料和方法:这是一项开放标记的前瞻性干预性研究。参与研究的手掌足底疣患者每2周在最大的疣内用胰岛素注射器注射10 IU (0.1 mL)的纯化蛋白衍生物,直到所有病变消失或最多注射6次。治疗结束后随访3个月。结果:共纳入54例患者,其中男性34例,女性20例。掌足底疣以足底分布最常见(48.1%)。其中,12例(22.2%)患者有甲周疣。在第6次治疗结束时,66.7%(36例)的掌足底疣患者的疣完全清除,没有任何疤痕,而33.3%(18例)的患者没有反应。不良反应为注射部位出现红斑、水肿和疼痛。结论:病灶内注射纯化蛋白衍生物是治疗掌足底疣的一种有效且经济的方法,疗效良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Prospective Clinical Study for Safety and Efficacy of Intralesional Tuberculin Purified Protein Derivative in Treatment of Palmoplantar Verruca
Background: Multiple treatment options are available for verruca, however none is completely effective. Conventional modalities such as salicylic acid, cryotherapy have inconsistent treatment efficacies. Newer modalities such as immunotherapy, bleomycin and lasers have shown higher clearance rates of warts in recent studies. Immunotherapy is an innovative approach to treat warts which relies on the principle of enhancement of cell-mediated immunity. This study was done to evaluate the efficacy of immunotherapy with Tuberculin Purified Protein Derivative injection in palmoplantar verruca in our context. Materials and Methods: This is an open labelled, prospective interventional study. Patients with palmoplantar verruca enrolled in the study were injected with purified protein derivative intralesionally by an insulin syringe at a dose of 10 IU (0.1 mL) in the largest wart every 2 weeks until all lesions disappeared or for a maximum of six sessions. They were followed up for 3 months after final treatment session. Results: A total of 54 patients, 34 males and 20 females, were enrolled in the study. Commonest distribution of palmoplantar verruca was in plantar distribution (48.1%). Among them, 12 (22.2%) patients had periungual warts. Complete clearance of warts without any scarring was seen in 66.7% (36) patients with palmoplantar verruca at the end of 6th session whereas 33.3% (18) patients did not respond. Adverse effects noted were erythema, edema and pain at injection site. Conclusion: Intralesional injection of purified protein derivative is an effective and inexpensive treatment option for palmo-plantar verruca with good outcome.  
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