抗生素浸渍骨水泥棒在控制骨感染中的作用及其在长骨感染性骨不连愈合中的作用

T. Pisal, Y. Hira, Swaroop Solunke, Shiva Basvaraj Sangam, Amol Patil, Shubanshu Gupta
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引用次数: 2

摘要

导论:尽管在固定方法、软组织管理和抗生素治疗方面取得了许多进展,但感染性骨不连的管理和治疗仍然是最具挑战性的临床问题之一。骨折部位的感染会导致内固定变得不稳定,并减缓骨折愈合。目的和目的:评估抗生素浸渍骨水泥棒在控制骨感染中的作用,并评估其在长骨感染性不愈合中的作用。材料和方法:这是一项前瞻性研究,包括在马哈拉施特拉邦西部三级保健中心进行的30例已确定的感染性长骨不愈合。有明确的临床和实验室证据证明感染的长骨骨干不连患者被纳入研究。结果:21例患者6个月或更早愈合。另外2例出现明显的愈伤组织形成。3例骨折部位6个月无骨痂形成。讨论:许多作者在他们的研究中证实庆大霉素和万古霉素是抗生素,即使暴露于聚甲基丙烯酸甲酯硬化引起的高温下也能保持活性。结论:从我们的研究中,我们证实使用抗生素浸渍骨水泥棒在控制骨感染方面具有重要作用,并且有助于长骨感染性不愈合的愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of antibiotic-impregnated bone cement rod in control of bone infection and assessing its role in union in cases of infective nonunion of long bones
INTRODUCTION: Managing and treating infected nonunion is one of the most challenging clinical scenarios despite numerous advances in the fixation methods, soft-tissue management, and antibiotic therapy. The infection of the fracture site causes internal fixation to become unstable and it slows down fracture healing. AIMS AND OBJECTIVES: To assess role of antibiotic-impregnated bone cement rod in control of bone infection and assessing its role in union in cases of infective nonunion of long bones. MATERIALS AND METHODS: This was a prospective study comprising of 30 cases of established infected nonunion of long bones carried out in a tertiary care center in Western Maharashtra. Patients of nonunion of long bone diaphysis with established clinical and laboratory evidence of infection were included in the study. RESULTS: Twenty-one cases showed complete union at 6 months or earlier. Two more cases showed significant callus formation. In three cases, there was no callus formation at fracture site till 6 months. DISCUSSION: Various authors in their studies confirmed that gentamicin and vancomycin are antibiotics which maintain activity even after being exposed to the high temperatures resulting from poly (methyl methacrylate) hardening. CONCLUSION: From our study, we confirm that the use of antibiotic-impregnated bone cement rod has a significant role in control of bone infection and also assists in union in cases of infective nonunion of long bones.
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