高通量电生理学在药物发现中的作用

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Protocols in Pharmacology Pub Date : 2019-12-01 DOI:10.1002/cpph.69

Chang Liu, Tianbo Li, Jun Chen

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引用次数: 16

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Role of High‐Throughput Electrophysiology in Drug Discovery

Due to their important physiological functions, ion channels are key therapeutic targets for a variety of disorders. However, electrophysiological assessment of ion channel activity is technically challenging and has been a bottleneck in the discovery of drugs that modulate channel function. To address this issue, automated patch clamp platforms have been developed with improved throughput and broader applications. An overview of the current status of high‐throughput electrophysiology and its applications in drug discovery is provided. © 2019 The Authors.

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Current Protocols in Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

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