肠道菌群多样性与T1DM发病:一项病例对照研究的初步数据

Q1 Medicine

Human Microbiome Journal Pub Date : 2017-12-01 DOI:10.1016/j.humic.2017.11.002

Deborah Traversi , Ivana Rabbone , Maria Giovanna Ignaccolo , Giulia Carletto , Irene Racca , Camilla Vallini , Violetta Andriolo , Francesco Cadario , Silvia Savastio , Roberta Siliquini , Franco Cerutti

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引用次数: 9

摘要

在过去的几十年里，1型糖尿病的发病率正在上升。近年来，微生物群的改变被认为是糖尿病前期和糖尿病的危险因素。意大利北部正在进行一项双中心病例对照研究。这里显示了初步结果。即使指纹图谱是异质的，微生物组聚类也显示了病例和对照组之间的划分。仅在少数患者中高度存在史密斯甲烷预防杆菌。病例和对照组的多样性指数和微生物序列似乎有很大的不同。结论性结果对评价的生物指标具有显著的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

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Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.

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来源期刊

Human Microbiome Journal Medicine-Infectious Diseases

自引率

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发文量

期刊介绍： The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.