替诺福韦阿拉那胺治疗48周后慢性乙型肝炎患者血脂的变化:一项前瞻性现实世界临床研究

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Yeqiong Zhang, Zhipeng Li, Q. Luo, Wenxiong Xu, Lu Wang, Shu Zhu, L. Peng, Chang Xie
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引用次数: 1

摘要

替诺福韦阿拉芬胺(TAF)是一种新的抗乙型肝炎病毒核苷酸类似物,可引起艾滋病患者血脂异常,但TAF对慢性乙型肝炎(CHB)患者血脂的影响尚不清楚。本研究旨在评估TAF对慢性乙型肝炎患者血脂水平的影响。方法121例CHB患者作为TAF组,其中treatment-naïve患者69例,TAF治疗前有核苷/核苷酸类似物治疗经验的患者52例。所有患者定期随访48周。比较TAF治疗前后总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)水平及血脂异常发生率。结果TAF治疗48周后,TAF组TC、tg、LDL-C水平均显著高于对照组。TAF组TC、TG水平明显高于基线。治疗48周后,基线TC和TG水平对TC和TG异常发生率有显著影响。LDL-C略有下降,但不明显。TC异常的患者比例从基线时的20.7%上升到第48周时的26.3%,LDL-C异常从50.4%下降到42.5%,TG异常从14.2%上升到22.5%。与对照组及基线比较均无显著差异。结论替诺福韦alafenamide治疗主要影响CHB患者TC和TG水平,对LDL-C影响不大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in blood lipids in patients with chronic hepatitis B after 48 weeks of tenofovir alafenamide treatment: A prospective real-world clinical study
Background Tenofovir alafenamide (TAF) is a new anti-hepatitis B virus nucleotide analogue that can cause dyslipidaemia in AIDS patients, but the effect of TAF on blood lipids in patients with chronic hepatitis B (CHB) is unknown. This study aimed to evaluate the effect of TAF on blood lipid levels in patients with CHB. Methods One hundred and twenty-one CHB patients were recruited as TAF group, including 69 treatment-naïve patients and 52 patients with nucleoside/nucleotide analogue experience before TAF treatment. All patients were followed up regularly for 48 weeks. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and the incidence of dyslipidaemia before and after TAF treatment were compared. Results After 48 weeks of TAF treatment, the levels of TC, TGs and LDL-C in TAF group were significantly higher than those in control group. In TAF group, the TC and TG levels were significantly higher than that at baseline. Baseline TC and TGs levels had a significant effect on the incidence of abnormal TC and TG levels after 48 weeks treatment. The LDL-C decreased slightly but not significantly. The proportion of patients with TC abnormalities increased from 20.7% at baseline to 26.3% at week 48, LDL-C abnormalities decreased from 50.4% to 42.5% and TG abnormalities increased from 14.2% to 22.5%. There were no significant differences compared with control group, as well as compared with baseline. Conclusions Tenofovir alafenamide treatment mainly affects the TC and TG level in patients with CHB but has little effect on LDL-C.
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来源期刊
Antiviral Therapy
Antiviral Therapy 医学-病毒学
CiteScore
2.60
自引率
8.30%
发文量
35
审稿时长
4-8 weeks
期刊介绍: Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.
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