{"title":"红霉素对白喉棒状杆菌的敏感性","authors":"Alif Mutahhar, Dwiyanti Puspitasari","doi":"10.20473/ijtid.v8i1.11654","DOIUrl":null,"url":null,"abstract":"Diphtheria is an acute infection disease caused by Corynebacterium diphtheria e . It remains a problem in Indonesia in a recent several years especially in East Java Province, which suffered from an outbreak of diphtheria in 201 1 . Erythromycin is the second line antibiotics therapy for diphteria if the patient is allergic to penicillin, also serving as a prophylactic and carrier therapy for contact diphtheria. Erythromycin has been used for diphtheria fo r a very long time, but there is little recent data on its sensitivity against C. diphtheriae. The purpose of this study is to identify whether Erythromycin still has a strong antibacterial activity against Corynebacterium diphtheriae by invitro test . This was a descriptive study which observed the sensitivity pattern of erythromycin against Corynebacterium diphtheria e using the E psilometer test (etest) as a diffusion technique . Samples used in this study were 30 isolate s of toxigenic Corynebacterium diphtheriae strain mitis and gravis at the Center for Health Laboratory (BBLK) Surabaya obtained during 2011 until 2014. We retrieved the data based on gender , age, and districts of patients for each of the samples then analyzed them descriptively. In this study , a sensitivity test of 30 toxigenic Corynebacterium diphtheriae isolate s revealed that 27 (90%) were sensitive to Erythromycin (average Minimum Inhibitory Concentration/ MIC) <0.016 μg/mL and all were strain mitis, while 3 (10%) had intermedi a t e sensitivity with MIC 1 μg/mL (all were strain gravis). No resistance result was found from the sensitivity test. According to the result, we conclude that Erythromycin still has a strong antibacterial activity against Corynebacterium diphtheriae.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SENSITIVITY OF ERYTHROMYCIN AGAINST CORYNEBACTERIUM DIPHTHERIAE\",\"authors\":\"Alif Mutahhar, Dwiyanti Puspitasari\",\"doi\":\"10.20473/ijtid.v8i1.11654\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Diphtheria is an acute infection disease caused by Corynebacterium diphtheria e . It remains a problem in Indonesia in a recent several years especially in East Java Province, which suffered from an outbreak of diphtheria in 201 1 . Erythromycin is the second line antibiotics therapy for diphteria if the patient is allergic to penicillin, also serving as a prophylactic and carrier therapy for contact diphtheria. Erythromycin has been used for diphtheria fo r a very long time, but there is little recent data on its sensitivity against C. diphtheriae. The purpose of this study is to identify whether Erythromycin still has a strong antibacterial activity against Corynebacterium diphtheriae by invitro test . This was a descriptive study which observed the sensitivity pattern of erythromycin against Corynebacterium diphtheria e using the E psilometer test (etest) as a diffusion technique . Samples used in this study were 30 isolate s of toxigenic Corynebacterium diphtheriae strain mitis and gravis at the Center for Health Laboratory (BBLK) Surabaya obtained during 2011 until 2014. We retrieved the data based on gender , age, and districts of patients for each of the samples then analyzed them descriptively. In this study , a sensitivity test of 30 toxigenic Corynebacterium diphtheriae isolate s revealed that 27 (90%) were sensitive to Erythromycin (average Minimum Inhibitory Concentration/ MIC) <0.016 μg/mL and all were strain mitis, while 3 (10%) had intermedi a t e sensitivity with MIC 1 μg/mL (all were strain gravis). No resistance result was found from the sensitivity test. According to the result, we conclude that Erythromycin still has a strong antibacterial activity against Corynebacterium diphtheriae.\",\"PeriodicalId\":13538,\"journal\":{\"name\":\"Indonesian Journal of Tropical and Infectious Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indonesian Journal of Tropical and Infectious Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20473/ijtid.v8i1.11654\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indonesian Journal of Tropical and Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20473/ijtid.v8i1.11654","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SENSITIVITY OF ERYTHROMYCIN AGAINST CORYNEBACTERIUM DIPHTHERIAE
Diphtheria is an acute infection disease caused by Corynebacterium diphtheria e . It remains a problem in Indonesia in a recent several years especially in East Java Province, which suffered from an outbreak of diphtheria in 201 1 . Erythromycin is the second line antibiotics therapy for diphteria if the patient is allergic to penicillin, also serving as a prophylactic and carrier therapy for contact diphtheria. Erythromycin has been used for diphtheria fo r a very long time, but there is little recent data on its sensitivity against C. diphtheriae. The purpose of this study is to identify whether Erythromycin still has a strong antibacterial activity against Corynebacterium diphtheriae by invitro test . This was a descriptive study which observed the sensitivity pattern of erythromycin against Corynebacterium diphtheria e using the E psilometer test (etest) as a diffusion technique . Samples used in this study were 30 isolate s of toxigenic Corynebacterium diphtheriae strain mitis and gravis at the Center for Health Laboratory (BBLK) Surabaya obtained during 2011 until 2014. We retrieved the data based on gender , age, and districts of patients for each of the samples then analyzed them descriptively. In this study , a sensitivity test of 30 toxigenic Corynebacterium diphtheriae isolate s revealed that 27 (90%) were sensitive to Erythromycin (average Minimum Inhibitory Concentration/ MIC) <0.016 μg/mL and all were strain mitis, while 3 (10%) had intermedi a t e sensitivity with MIC 1 μg/mL (all were strain gravis). No resistance result was found from the sensitivity test. According to the result, we conclude that Erythromycin still has a strong antibacterial activity against Corynebacterium diphtheriae.