线粒体功能障碍在糖尿病并发症发病机制和治疗中的新作用

Q4 Medicine

中华内分泌代谢杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1000-6699.2020.02.014

H. Qu, Yi Zheng, Xiaoli Gong, Hongting Zheng

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引用次数: 0

摘要

线粒体功能障碍在糖尿病并发症的发病机制中起着重要作用，针对这些疾病的线粒体功能的治疗策略越来越受到关注。我们的团队一直致力于探索线粒体功能障碍（如线粒体氧化应激和能量代谢）以及各种糖尿病并发症之间的关系。这篇综述强调了线粒体功能障碍在糖尿病溃疡、糖尿病肾病、糖尿病合并非酒精性脂肪肝发病机制中的作用及其相应分子途径的最新进展，试图探索靶向线粒体功能障碍治疗这些疾病的可行性。关键词：线粒体；功能障碍；糖尿病；并发症

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The emerging role of mitochondrial dysfunction in the pathogenesis and treatment of diabetic complications

Mitochondrial dysfunction plays an important role in the pathogenesis of diabetic complications, and more attention has been paid to the treatment strategies targeting mitochondrial function in these diseases. Our group has been devoted to exploring the relationship between mitochondrial dysfunction such as mitochondrial oxidative stress and energy metabolism, as well as various diabetic complications. This review highlighted recent progresses in the role of mitochondrial dysfunction in the pathogenesis of diabetic ulcer, diabetic nephropathy, diabetes complicated with nonalcoholic fatty liver and their correspondent molecular pathways, tried to explore the feasibility of targeting mitochondrial dysfunction in the treatment of these diseases. Key words: Mitochondria; Dysfunction; Diabetes mellitus; Complications

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来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.