犬全身性淋巴结病伴CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ t区淋巴瘤1例

Q4 Veterinary

Korean Journal of Veterinary Research Pub Date : 2021-09-30 DOI:10.14405/kjvr.2021.61.e21

S. Shin, Yu‐Jin Lim, Hyeona Bae, Jihu Kim, ARom Cho, Jinho Park, Dongbin Lee, D. Jung, Sang-Ki Kim, Dohyeon Yu

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引用次数: 2

摘要

犬T区淋巴瘤（TZL）是一种成熟的犬T细胞淋巴瘤。如果没有活组织检查或流式细胞术的免疫表型，诊断和亚分类是不可能的。一只11岁、已绝育的雌性金毛寻回犬出现淋巴结肿大。临床检查与犬多中心淋巴瘤一致。然而，免疫表型显示CD3、CD4、CD5、CD8、CD21、TCRαβ和MHCII呈阳性，但CD34、CD45、CD79a和TCRγδ呈阴性。组织病理学显示淋巴细胞向皮层扩张，保留了结包膜的结构和变薄，CD3阳性但PAX-5阴性。由于TZL的惰性，在没有临床干预的情况下采用了仔细的监测方法。

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CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: a case report

Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCRαβ, and MHCII but negative for CD34, CD45, CD79a, and TCRγδ. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.

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来源期刊

Korean Journal of Veterinary Research Veterinary-Veterinary (all)

CiteScore

0.50

自引率

0.00%

发文量