Gel of Betel (Areca Catechu Linn.) Nut Ethanol Extract Activity Test as Cuts Healing against Diabetic Rabbits (Oryctolagus cuniculus)

Background: Areca nut (Areca catechu Linn.) contains the main components in the form of tannins, flavonoids, alkaloids, and saponins. People usually use the young betel nut as cuts medicine by mashing it and applying it directly to the cuts cut area or by boiling the betel nut and the boiled water is used to clean cuts and other skin infections. Objective: The purpose of this study was to determine the effect of giving betel nut (Areca catechu Linn.) ethanol extract gel and to determine the most effective concentration of cuts healing in diabetic rabbits (Oryctolagus cuniculus). Method: This study used 6 treatment groups, namely the group that was given a gel with an extract concentration of 1%, 3%, and 5%, a group that was given conventional preparations as a positive control, a group that was given a gel base as a negative control, and a group that was not given the test substance. The rabbit's back area was anesthetized with 2% lidocaine subcutaneously and a 2 cm long incision was made with a depth of 1.5 mm using a scalpel. The data obtained were the percentage of cuts healing in diabetic rabbits which were analyzed using One-way ANOVA. Results: The results showed that the percentage of cuts healing was 100% healed on gel treatment with 1% areca nut ethanol extract on the 11th day, gel with 3% betel nut ethanol extract on the 11th day, and gel with 5% betel nut ethanol extract on the 10th day. The results of One-way ANOVA statistical analysis showed a significant difference in the cuts healing effect of diabetic rabbits in each treatment with a value of p = 0.000 (p <0.05). Conclusion: The results of the study concluded that areca nut has activity in cuts healing in diabetic rabbits which was formulated in the form of a gel with an extract concentration of 5%.