天然产物和合成衍生物作为治疗被忽视热带病的有希望的候选者

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Orbital: The Electronic Journal of Chemistry Pub Date : 2022-12-28 DOI:10.17807/orbital.v14i4.16374

Ana Flávia dos Santos Fuzaro, Carolina Sousa Ponciano, J. C. Barros, Richard M. Grazul, Mauro Vieira de Almeida, Eloah Pereira Ávila

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引用次数: 0

摘要

被忽视的热带病(NTD)是一组地方病，每年造成多达100万人死亡。利什曼病和恰加斯病被列为非传染性疾病，其目前的治疗途径有限。迫切需要开发新的药物来对抗或减轻这些疾病的症状。目前的工作重点是几种天然产物及其衍生物的活性，这些产物已经对这两种疾病的致病寄生虫进行了测试。天然产物的活动说明了它们在防治非传染性疾病方面的潜力。这一领域的研究可以为推进医学研究和向低收入和中等收入国家提供治疗提供机会。

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Natural Products and Synthetic Derivatives as Promising Candidates Against Neglected Tropical Diseases

Neglected Tropical Diseases (NTD) are a group of endemic diseases that cause up to one million deaths annually. Leishmaniasis and Chagas Disease are classified as NTD whose current treatments are of limited access. There is an urgent need to develop new agents to combat or alleviate the symptoms of these pathologies. The present work highlights the activities of several natural products and their derivatives which have been tested against the causative parasites of both diseases. The activities of natural products illustrate their potential to assist in the combat against NTD. Research in this area could provide an opportunity to advance medical research and to provide treatments to low- and middle-income countries.

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来源期刊

Orbital: The Electronic Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： Orbital: The Electronic Journal of Chemistry is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Original contributions (in English) are welcome, which focus on all areas of Chemistry and their interfaces with Pharmacy, Biology, and Physics. Neither authors nor readers have to pay fees. The journal has an editorial team of scientists drawn from regions throughout Brazil and world, ensuring high standards for the texts published. The following categories are available for contributions: 1. Full papers 2. Reviews 3. Papers on Education 4. History of Chemistry 5. Short communications 6. Technical notes 7. Letters to the Editor The Orbital journal also publishes a number of special issues in addition to the regular ones. The central objectives of Orbital are threefold: (i) to provide the general scientific community (at regional, Brazilian, and worldwide levels) with a formal channel for the communication and dissemination of the Chemistry-related literature output by publishing original papers based on solid research and by reporting contributions which further knowledge in the field; (ii) to provide the community with open, free access to the full content of the journal, and (iii) to constitute a valuable channel for the dissemination of Chemistry-related investigations.