瑞非尼后的序列治疗和转移性结直肠癌的生存:一项定性临床回顾

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2021-03-01 DOI:10.2217/crc-2022-0006

S. Babajanyan, Megan Pollack, Sarah Castelo, A. Kavati, T. Bekaii-Saab

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引用次数: 0

摘要

对于难治性转移性结直肠癌(mCRC)患者服用瑞非尼的治疗顺序和结果，目前的循证指导有限。我们进行了一项有针对性的文献综述，以确定与瑞非尼治疗相关的临床结果以及瑞非尼治疗后的后续治疗。9项基于序列生存数据的研究中，reorafenib在难治性mCRC后续治疗前的中位总生存期为2.1-19.3个月。在mCRC中，在其他治疗之前接受瑞非尼治疗的患者的安全性结果通常与后续药物临床试验中报告的不良事件相当。本综述的数据表明，难治性mCRC患者在化疗或靶向治疗前使用瑞非尼与生存率之间存在潜在的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sequenced treatment after regorafenib and survival in metastatic colorectal cancer: a qualitative clinical review

There is limited evidence-based guidance regarding treatment sequencing and outcomes following regorafenib in patients with refractory metastatic colorectal cancer (mCRC). A targeted literature review was conducted to identify studies with clinical outcomes associated with regorafenib therapy and subsequent treatment following regorafenib therapy. The median overall survival range of the nine studies with sequenced-based survival data was 2.1–19.3 months for regorafenib prior to subsequent therapy in refractory mCRC. Safety outcomes in patients treated with regorafenib prior to other therapies in mCRC were generally comparable to reported adverse events in clinical trials for subsequent agents. Data from this review demonstrate a potential correlation between survival and the use of regorafenib prior to subsequent chemotherapy or targeted therapy in patients with refractory mCRC.

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.