环境烟草烟雾暴露对儿童哮喘发病时间的全基因组相互作用研究

IF 2.7 4区医学 Q2 GENETICS & HEREDITY

Genes and Environment Pub Date : 2018-09-15 DOI:10.1183/13993003.CONGRESS-2018.PA1278

P. Sugier, C. Sarnowski, R. Granell, C. Laprise, D. Jarvis, M. Ege, E. Mutius, M. Dizier, A. J. Henderson, M. Kogevinas, F. Demenais, E. Bouzigon

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引用次数: 1

摘要

1血清，UMR-946，遗传变异和人类疾病股；巴黎狄德罗大学；巴黎皮埃尔和玛丽·居里大学（法国），2伦敦大学，UMR-946，遗传变异和人类疾病科；巴黎-狄德罗大学（法国），3人口健康科学，布里斯托尔医学院，布里斯托尔大学（英国），魁北克大学基础科学部；Saguenay大学社会服务中心-Lac Saint-Jean Chicoutimi（加拿大），5帝国理工学院国家心肺研究所传染病流行病学、职业医学和公共卫生；MRC-PHE伦敦环境与健康中心（英国），路德维希·马克西米利安大学6Dr von Hauner儿童医院；慕尼黑综合肺病中心（CPC-M），德国慕尼黑肺部研究中心（德国），7ISGlobal，西班牙巴塞罗那；庞培法布拉大学，西班牙加泰罗尼亚巴塞罗那；西班牙马德里流行病研究所；巴塞罗那市医学研究所（IMIM医院）（西班牙）

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Genome-wide interaction study of environmental tobacco smoke exposure on time-to-asthma onset in childhood

1Inserm, UMR-946, Genetic Variation and Human Diseases Unit; Université Paris Diderot; Université Pierre et Marie Curie Paris (France), 2Inserm, UMR-946, Genetic Variation and Human Diseases Unit; Université Paris Diderot Paris (France), 3Population Health Sciences, Bristol Medical School, University of Bristol Bristol (United Kingdom), 4Département des sciences fondamentales, Université du Québec à Chicoutimi; Centre intégré universitaire de santé et de services sociaux du Saguenay–Lac-Saint-Jean Chicoutimi (Canada), 5Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College; MRC-PHE Centre for Environment & Health London (United Kingdom), 6Dr von Hauner Children's Hospital, Ludwig Maximilian University; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research Munich (Germany), 7ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Municipal Institute of Medical Research (IMIM-Hospital del Mar) Barcelona (Spain)

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来源期刊

Genes and Environment Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

27 weeks

期刊介绍： Genes and Environment is an open access, peer-reviewed journal that aims to accelerate communications among global scientists working in the field of genes and environment. The journal publishes articles across a broad range of topics including environmental mutagenesis and carcinogenesis, environmental genomics and epigenetics, molecular epidemiology, genetic toxicology and regulatory sciences. Topics published in the journal include, but are not limited to, mutagenesis and anti-mutagenesis in bacteria; genotoxicity in mammalian somatic cells; genotoxicity in germ cells; replication and repair; DNA damage; metabolic activation and inactivation; water and air pollution; ROS, NO and photoactivation; pharmaceuticals and anticancer agents; radiation; endocrine disrupters; indirect mutagenesis; threshold; new techniques for environmental mutagenesis studies; DNA methylation (enzymatic); structure activity relationship; chemoprevention of cancer; regulatory science. Genetic toxicology including risk evaluation for human health, validation studies on testing methods and subjects of guidelines for regulation of chemicals are also within its scope.