心脏系统中TRAPP复合物的生化结构和功能

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2023-12-01 DOI:10.1016/j.jacbts.2023.03.011

Peter Papaioannou BS , Michael J. Wallace BS , Nipun Malhotra MSc , Peter J. Mohler PhD , Mona El Refaey PhD

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引用次数: 0

摘要

据报道，转运蛋白颗粒（TRAPP）在高尔基体和内质网内蛋白质产物的转运过程中发挥着重要作用。TRAPP的功能障碍与神经和心血管系统疾病有关，但大多数文献只关注TRAPP在神经系统中的功能。在此，我们重点介绍 TRAPP 的已知通路，并假设 TRAPP 功能障碍对心血管系统的潜在影响，特别是 TRAPP 作为 Rab1 和 Rab11 的鸟嘌呤核苷酸交换因子的作用。我们还回顾了与 TRAPP 复合物及其亚基变化相关的各种心血管表型。

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Biochemical Structure and Function of TRAPP Complexes in the Cardiac System

Trafficking protein particle (TRAPP) is well reported to play a role in the trafficking of protein products within the Golgi and endoplasmic reticulum. Dysfunction in TRAPP has been associated with disorders in the nervous and cardiovascular systems, but the majority of literature focuses on TRAPP function in the nervous system solely. Here, we highlight the known pathways of TRAPP and hypothesize potential impacts of TRAPP dysfunction on the cardiovascular system, particularly the role of TRAPP as a guanine-nucleotide exchange factor for Rab1 and Rab11. We also review the various cardiovascular phenotypes associated with changes in TRAPP complexes and their subunits.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.