湿罐和柠檬烯对糖尿病大鼠氧化应激及生化指标的影响

IF 1 Q4 PHARMACOLOGY & PHARMACY
Mohsen Alizadeh, Amir Hossein Nafari, Forouzan Hadipour Moradi, F. Beyranvand, H. Ahmadvand, M. Birjandi, S. Bagheri, A. Kiani
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引用次数: 0

摘要

背景:根据国际糖尿病联合会的数据,到2045年,将有6.29亿成年人患有糖尿病。湿拔罐疗法是出血和干拔罐的结合,在传统医学中被用作糖尿病的补充疗法。柠檬烯被证明具有抗氧化和抗糖尿病活性,但其与其他治疗方法的潜力尚未得到彻底探索。目的:尽管湿拔罐疗法在不同的条件下被广泛使用,但它在治疗糖尿病方面的潜力还没有得到很好的检验。方法:雄性Wistar大鼠注射四氧嘧啶和烟酰胺诱发糖尿病。拔罐后,测定大鼠血清一氧化氮、肌酸酐、SGPT、SGOT、胆固醇、甘油三酯、葡萄糖、GPX、尿素和HDL水平。然后测定血清、肾脏和肝脏的谷胱甘肽、过氧化氢酶、谷胱甘肽过氧化物酶、丙二醛和蛋白质水平。结果:与糖尿病大鼠相比,接受湿法拔罐和柠檬烯的糖尿病大鼠的血糖水平、接受柠檬烯或柠檬烯和湿法拔罐的糖尿病大白鼠的血清谷胱甘肽水平、接受柠烯和湿法拔罐的对照大鼠的肝GSH水平、,以及与对照组相比,接受柠檬烯和湿拔罐的对照大鼠的肝脏过氧化氢酶活性。血清no、蛋白质、肌酸酐、SGPT、SGOT、胆固醇、甘油三酯MDA、尿素、过氧化氢酶、高密度脂蛋白、肾GSH、MDA、过氧化氢酶和肝蛋白及MDA水平无显著变化。结论:本研究结果表明,柠檬烯和湿法拔罐治疗可以作为降低糖尿病大鼠血糖升高的药物。需要进一步的临床研究来证实这一发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Wet Cupping (Al-hijamah) and Limonene on Oxidative Stress and Biochemical Parameters in Diabetic Rats
Background: According to the international diabetes federation, 629 million adults will suffer from diabetes by 2045. Wet cupping therapy is a combination of bleeding and dry cupping and has been used in traditional medicine as a complementary therapy for diabetes. Limonene was shown to have both antioxidant and antidiabetic activity but its potential alongside other treatments has not been thoroughly explored. Objectives: Although wet-cupping therapy is widely used under different conditions, its potential in the treatment of diabetes is not well-examined. Methods: Male Wistar rats were then injected with alloxan and nicotinamide to induce diabetes. After cupping, the rats’ serum nitric oxide, creatinine, SGPT, SGOT, cholesterol, triglyceride, glucose, GPX, urea, and HDL levels were determined. The glutathione, catalase, glutathione peroxidase, malondialdehyde, and protein level of the serum, renal, and liver were then measured. Results: The results showed a significant differences in serum glucose levels among the diabetic rats receiving wet cupping and limonene, in serum glutathione levels in diabetic rats receiving limonene or limonene and wet cupping compared to the diabetic rats, in liver GSH levels in control rats receiving limonene and wet cupping, in the liver GPX activity in control rats receiving limonene, and in liver catalase activity in control rats receiving limonene and wet cupping compared to control group. There was no significant change in serum NO, protein, creatinine, SGPT, SGOT, cholesterol, triglyceride MDA, urea, catalase, HDL, renal GSH, MDA, catalase, liver protein, and MDA Level. Conclusions: The findings of the present study suggested that a combination of limonene and wet cupping therapy could be presented as an agent to lower elevated blood glucose levels in diabetic rats. Further clinical studies are required to confirm the findings.
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CiteScore
1.40
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