原子力显微镜研究进展综述

Q4 Medicine

Open Neuroimaging Journal Pub Date : 2018-12-31 DOI:10.2174/1874440001812010086

S. Maghsoudy-Louyeh, M. Kropf, B. Tittmann

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引用次数: 11

摘要

生物样品的研究是原子力显微镜AFM最具吸引力和创新性的应用领域之一。最近在软件和硬件方面的突破彻底改变了这一领域，本文报道了最近的趋势，并描述了在生物样品上的应用实例。AFM最初是为高分辨率成像目的而开发的，作为一种纳米压头，它还具有独特的能力，可以探测培养中活细胞的动态粘弹性材料特性。特别是，AFM弹性成像结合了成像和压痕模态来绘制细胞力学性能的空间分布，进而反映底层结构的结构和功能。本文介绍了原子力显微镜在动植物细胞结构中的应用进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Review of Progress in Atomic Force Microscopy

The study of biological samples is one of the most attractive and innovative fields of application of atomic force microscopy AFM. Recent breakthroughs in software and hardware have revolutionized this field and this paper reports on recent trends and describes examples of applications on biological samples. Originally developed for high-resolution imaging purposes, the AFM also has unique capabilities as a nano-indentor to probe the dynamic visco-elastic material properties of living cells in culture. In particular, AFM elastography combines imaging and indentation modalities to map the spatial distribution of cell mechanical properties, which in turn reflect the structure and function of the underlying structure. This paper describes the progress and development of atomic force microscopy as applied to animal and plant cell structures.

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来源期刊

Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.