深海衍生真菌烟曲霉CBC18132的聚酮和生物碱

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-08-06 DOI:10.25135/rnp.348.2204.2447

Zhongbin Cheng, Yu Liu, F. Yang, Xiaoqian Zhang, Ying-Chun Qiao, Wei Xu, Qin Li

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引用次数: 1

摘要

：对从深海沉积物中分离得到的烟曲霉CBC18132菌株的次生代谢产物进行了研究。在大米培养基上发酵，然后进行色谱分离，分离出三种聚酮（1−3）和十种生物碱（4−13）。通过分析光谱数据（1H和13C NMR以及MS数据）来确定结构。蒽醌衍生物胰蛋白酶（1）的绝对构型首次通过ECD和比旋计算相结合的方法得到解析。描述了化合物1−3可能的生物成因关系。所有分离的化合物对 -初始浓度为4mM的葡萄糖苷酶。

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Polyketides and Alkaloids from the Deep-Sea-Derived Fungus Aspergillus fumigatus CBC18132

: The fungal strain Aspergillus fumigatus CBC18132, isolated from deep-sea sediment, was investigated for secondary metabolites. Fermentation on rice medium followed by chromatographic separation led to the isolation of three polyketides ( 1 − 3 ) and ten alkaloids ( 4 − 13 ). The structures were determined by analyses of spectroscopic data ( 1 H and 13 C NMR, and MS data). The absolute configuration of the anthraquinone-derivative trypacidin ( 1 ) was resolved for the first time by a combination of ECD and specific rotation calculation. The probable biogenetic relationships of compounds 1 − 3 were described. All isolated compounds were inactive toward the  -glucosidase at the initial concentration of 4 mM.

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.