砷剂在大鼠急性和亚急性毒性研究中的安全性评价

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2023-05-23 DOI:10.18311/ti/2023/v30i2/32299

Roshan Lal, M. Sharma, S. Behera, R. K. Regar, Deepika Tripathi, G. N. Kumar, Satvinder Singh, D. Verma, Pankaj Gupta, S. Kaushik, A. Khurana

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引用次数: 1

摘要

砷相册经常被用于治疗许多疾病的顺势疗法。然而，其安全数据不可用。因此，本研究的目的是评估砷专辑6C、30C和200C对大鼠的口服毒性。砷相册（6C、30C和200C）的急性毒性剂量为2000μl/kg，观察时间长达14天。对于亚急性毒性，给药28天，观察临床症状、体重变化和死亡率。评估血液学、生化、器官重量和组织病理学分析。结果表明，砷相册急性毒性无死亡，LD50＞2000μl/kg。在亚急性毒性研究中，砷相册（200μl/kg）在上述参数中没有显示出任何显著变化。可以得出结论，在大鼠中以200μl/kg的剂量长期口服砷相册（6C、30C和200C）是安全的，并且不会产生毒性。

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Safety Evaluation of Arsenicum Album in Acute and Sub-Acute Toxicity Studies in Rats

Arsenic album is frequently prescribed in homoeopathy for many diseases. However, its safety data is not available. Thus, the study’s purpose is to evaluate the oral toxicity of Arsenic album 6C, 30C, and 200C in rats. Arsenic album (6C, 30C, and 200C) was given at 2000 μl/kg for acute toxicity and observed for up to 14 days. For subacute toxicity, it was given for 28 days and observed for clinical signs, change in body weight and Mortality. Hematological, biochemical, organ weight and histopathological analyses were assessed. Results indicate no mortality of arsenic album in acute toxicity and LD50 is >2000 μl/kg. In the subacute toxicity study, arsenic album (200 μl/kg) did not show any significant changes in above parameters. It may be concluded that the arsenic album (6C, 30C, and 200C) is safe and produces no toxicity when administered orally for a prolonged duration at 200 μl/kg in rats.

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.