7-羟基-4-取代香豆素的有效合成研究

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2022-01-01 DOI:10.1515/hc-2022-0154

Dejun Zhou, Youchao Zhuang, Zuntian Sheng

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引用次数: 0

摘要

摘要许多香豆素衍生物在荧光探针中具有良好的生物活性和应用价值。因此，香豆素衍生物的合成路线也引起了许多研究小组的关注。本工作基于Pechmann香豆素的合成方法，讨论了各种路易斯酸对反应的影响，并探讨了7-羟基-4-取代香豆素的最佳合成条件。根据实验结果，提出了香豆素的可能机理，为香豆素的工业化生产提供了参考。

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Study on effective synthesis of 7-hydroxy-4-substituted coumarins

Abstract Many coumarin derivatives have good biological activity and application value in fluorescent probes. Therefore, synthetic routes to coumarin derivatives have also attracted the attention of many research groups. In this work, based on the Pechmann coumarin synthesis method, the influence of various Lewis acids on the reaction was discussed, and the optimal synthesis conditions of 7-hydroxy-4-substituted coumarins were explored. Based on the experimental results, a possible mechanism was proposed, which provides a reference for future industrialized production of coumarins.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.