P.62斜枫异黄酮和乙醇提取物对实验性糖尿病的影响

IF 0.9 4区医学 Q4 PERIPHERAL VASCULAR DISEASE

Artery Research Pub Date : 2020-12-01 DOI:10.2991/artres.k.201209.071

K. Duru, C. Hildreth, A. Avolio, J. Phillips, M. Butlin

{"title":"P.62斜枫异黄酮和乙醇提取物对实验性糖尿病的影响","authors":"K. Duru, C. Hildreth, A. Avolio, J. Phillips, M. Butlin","doi":"10.2991/artres.k.201209.071","DOIUrl":null,"url":null,"abstract":"Methods: Diabetes was induced (streptozotocin 65 mg/kg, nicotinamide 110 mg/kg) in 9 male Wistar rats (12 weeks old). 9 additional rats were healthy controls. After 4 weeks animals were treated for 4 weeks with vehicle, isoflavone (200 mg/kg/day), or Inonotus obliquus (100 mg/kg/day). Blood pressure and metabolic caging were measured weekly. Glucose tolerance, renal function (serum creatinine, blood urea nitrogen (BUN) level, creatinine clearance rate) and heart, kidney and body weight were assessed at the end-point.","PeriodicalId":8466,"journal":{"name":"Artery Research","volume":" ","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"P.62 Assessment of Isoflavone and Ethanolic Extract of Inonotus Obliquus on Experimentally Induced Diabetes\",\"authors\":\"K. Duru, C. Hildreth, A. Avolio, J. Phillips, M. Butlin\",\"doi\":\"10.2991/artres.k.201209.071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Methods: Diabetes was induced (streptozotocin 65 mg/kg, nicotinamide 110 mg/kg) in 9 male Wistar rats (12 weeks old). 9 additional rats were healthy controls. After 4 weeks animals were treated for 4 weeks with vehicle, isoflavone (200 mg/kg/day), or Inonotus obliquus (100 mg/kg/day). Blood pressure and metabolic caging were measured weekly. Glucose tolerance, renal function (serum creatinine, blood urea nitrogen (BUN) level, creatinine clearance rate) and heart, kidney and body weight were assessed at the end-point.\",\"PeriodicalId\":8466,\"journal\":{\"name\":\"Artery Research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2020-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Artery Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2991/artres.k.201209.071\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Artery Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2991/artres.k.201209.071","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

摘要

方法:用链脲佐菌素65 mg/kg、烟酰胺110 mg/kg诱导9只12周龄雄性Wistar大鼠患糖尿病。另外9只大鼠作为健康对照。4周后，动物分别用异黄酮(200 mg/kg/d)、异黄酮(100 mg/kg/d)或斜凤尾草(100 mg/kg/d)治疗4周。每周测量血压和代谢笼化。葡萄糖耐量、肾功能(血清肌酐、血尿素氮(BUN)水平、肌酐清除率)、心脏、肾脏和体重在终点进行评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

P.62 Assessment of Isoflavone and Ethanolic Extract of Inonotus Obliquus on Experimentally Induced Diabetes

Methods: Diabetes was induced (streptozotocin 65 mg/kg, nicotinamide 110 mg/kg) in 9 male Wistar rats (12 weeks old). 9 additional rats were healthy controls. After 4 weeks animals were treated for 4 weeks with vehicle, isoflavone (200 mg/kg/day), or Inonotus obliquus (100 mg/kg/day). Blood pressure and metabolic caging were measured weekly. Glucose tolerance, renal function (serum creatinine, blood urea nitrogen (BUN) level, creatinine clearance rate) and heart, kidney and body weight were assessed at the end-point.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Artery Research Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

16.70%

发文量

审稿时长

13 weeks

期刊介绍： Artery Research is the official journal of the Association for Research into Arterial Structure and Physiology (ARTERY) which promotes the advancement of knowledge and dissemination of information concerning the pathophysiology, epidemiology, detection, investigation and treatment of arterial structure and function. The journal publishes original research articles, review articles, perspectives, case-studies, letters to the Editor, short communications and images. All submitted material is subject to a strict peer-review process.