人类类器官：理解生物学和治疗疾病的工具。

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2020-01-24 DOI:10.1146/annurev-pathmechdis-012419-032611

Frans Schutgens, H. Clevers

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引用次数: 249

摘要

类器官是体外培养的三维结构，概括了体内器官的关键方面。它们可以从多能干细胞和成体干细胞中建立，后者是本综述的主题。源自成人干细胞的类器官利用了由这些细胞驱动的组织再生过程，它们可以直接从许多器官的健康或患病上皮中建立。类器官适用于为细胞系开发的任何实验方法。在实验生物学中的应用涉及组织生理学和疾病的建模，包括恶性、遗传性和感染性疾病。患者来源的肿瘤类器官的生物库被用于药物开发研究，它们有望开发个性化和再生医学。在这篇综述中，我们讨论了成人干细胞衍生类器官在实验室和临床中的应用。《病理学年度评论：疾病机制》第15卷预计最终在线出版日期为2020年1月24日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Human Organoids: Tools for Understanding Biology and Treating Diseases.

Organoids are in vitro-cultured three-dimensional structures that recapitulate key aspects of in vivo organs. They can be established from pluripotent stem cells and from adult stem cells, the latter being the subject of this review. Organoids derived from adult stem cells exploit the tissue regeneration process that is driven by these cells, and they can be established directly from the healthy or diseased epithelium of many organs. Organoids are amenable to any experimental approach that has been developed for cell lines. Applications in experimental biology involve the modeling of tissue physiology and disease, including malignant, hereditary, and infectious diseases. Biobanks of patient-derived tumor organoids are used in drug development research, and they hold promise for developing personalized and regenerative medicine. In this review, we discuss the applications of adult stem cell-derived organoids in the laboratory and the clinic. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 15 is January 24, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.