大鼠照射后白细胞的恢复:单次和双次(重复)X射线照射后

IF 0.1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Mohammed Sirage Ibrahim, Mathew G. Abubakar, N. Chigozie, Geoffrey Lunsti, Paul Bura
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引用次数: 0

摘要

目的:本研究旨在确定辐射对Albino Wister大鼠单次和双次(重复)X射线照射后外周血白细胞(WBCs)的影响及其完全恢复的时间,以便在任何射线照相检查中方便地推荐重复辐射的安全期。材料和方法:21只健康的白化Wister大鼠,年龄在2-4个月之间,体重约140-200克,用于本研究。他们被分为A、B和C三组。B和C组用诊断X光机的X射线照射。C组立即以相同的暴露因子再次照射,间隔约3-4分钟。在30分钟至7天的时间内收集来自对照组和实验组(照射后)的血液样本,并进行标准血液学检查以确定WBC计数和差异白细胞计数。结果:照射30min后,单次照射组WBC明显下降。然而,这在双重暴露组中更为明显。这种下降一直持续到照射后48小时。两个实验组的WBC计数在照射后第3天和第4天恢复正常。记录的最大修复和恢复率为正常计数的单次暴露的98.6%和双次暴露的95.9%。结论:本研究表明,经照射的外周血白细胞的回收率不是100%,在双重(重复)照射的细胞中效果更显著。在重复检查之前,应允许细胞从先前的照射中恢复至少3-7天的安全期。这将作为放射技师/放射科医生管理需要后续检查的患者的指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Postirradiation white blood cell recovery in rats: Following single and double (repeated) X-ray exposure
Purpose: This study aims at determining the effect of radiation on peripheral white blood cells (WBCs) and the time for their full recovery in Albino Wister Rats following single and double (repeated) X-ray exposure so that a safe period for repeated irradiation can conveniently be recommended for any radiographic examination. Materials and Methods: Twenty one healthy albino Wister Rats of aged between 2–4 month and weighing about 140–200 g were used for this study. They were divided into three Groups A, B, and C. Group B and C were irradiated with X-ray from a diagnostic X-ray machine. Group C was immediately irradiated again with the same exposure factors at about 3–4 min interval. Blood samples from both control and experimental groups (after irradiation) were collected through a period of 30 min to 7 days and subjected to standard hematologic examination to determine the WBC count and differential leukocytes count. Results: A sharp fall in WBC was observed in the single-exposed group 30 min following irradiation. This is however more pronounced in the double-exposed group. This fall persisted till 48 h after irradiation. The WBC count returned to normal on the 3rd and 4th day following irradiation for both experimental groups. The maximum repair and recovery recorded were 98.6% for single exposure and 95.9% for double exposure of the normal count. Conclusion: This study has presented that the recovery of an irradiated peripheral WBC is not 100% and that the effect is more remarkable in cells with double (repeated) irradiation. A safe period of at least 3–7 days should be allowed for the cells to recover from previous irradiation before an examination is repeated. This will serve as a guide to radiographers/radiologist in the management of patients who need follow-up examinations.
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来源期刊
West African Journal of Radiology
West African Journal of Radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
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