Soderm®-Forte凝胶与Cytoflavin®联合应用于实验性牙周炎大鼠牙龈组织的病理形态学分析

Q3 Pharmacology, Toxicology and Pharmaceutics
P. Galenko-Yaroshevsky, A. Slavinskiy, Mark A. Zadorozhniy, V. K. Leontev, Artur V. Kheigetyan, V. Popkov, A. Zelenskaya, Lyudmila M. Chuprinenko, A. A. Verevkin, Izabella G. Lomsadze, Mariya Yu. Materenchuk, S. Lebedeva
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引用次数: 1

摘要

前言:牙周炎是现代牙科最紧迫的问题之一。开发新的牙周炎患者联合治疗模式和方案是药理学家和牙医的一项战略任务。鉴于此,病理形态学检查具有高度重要性,因为它使我们能够以高度客观性得出所给药物的治疗效果的结论。研究目的:评价Soderm®-Fote和Cytoflain®的组成对实验性牙周炎(EP)大鼠牙龈组织病理形态学模式的影响。材料和方法:采用结扎法模拟EP。研究设计:具有完整牙周组织的动物;患有未经治疗的EP的动物;用传统药物治疗(TDT)治疗EP的动物;用TDT和Soderm®-Fote凝胶组合治疗EP的动物;以及用TDT、Soderm®-Fote和细胞黄素®联合治疗的EP动物。为了进行病理形态学检查,活检标本取自下切牙的牙龈边缘。载玻片用苏木精和伊红以及Masson染色。使用ImageJ软件进行计算机形态测量。结果:在EP中,TDT对牙龈的病理形态学变化具有中等的积极作用。TDT和Soderm®-Fote的组合,以及在更大程度上,TDT、Soderm™-Fote和细胞黄素®的组合具有很高的治疗效果,其特征是牙龈组织的快速再生。结论:TDT、Soderm®-Fote和细胞黄素®联合治疗EP具有更显著的治疗效果,表现为早期病变消退和加速牙龈组织再生。图形摘要
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathomorphological analysis of the gum tissues in the application of the combination of Soderm®-Forte gel with Cytoflavin® in experimental periodontitis in rats
Introduction: Periodontitis is one of the most urgent problems of modern dentistry. The development of new paradigms and regimens of combination therapy of patients with periodontitis is a strategic task for pharmacologists and dentists. In view of this, pathomorphological examination is of high importance, since it allow us to conclude about the therapeutic effectiveness of the administered drugs with high objectivity. Aim of the study: to evaluate the effect of the composition of Soderm®-Forte and Cytoflavin® on the pathomorphological pattern of gum tissues of rats with experimental periodontitis (EP). Materials and Methods: EP was simulated in rats by ligature method. Study design: animals with intact periodontium; animals with untreated EP; animals with EP treated with traditional drug therapy (TDT); animals with EP treated with the combination of TDT and Soderm®-Forte gel; and animals with EP treated with the combination of TDT, Soderm®-Forte and Cytoflavin®. For pathomorphological examination, biopsy specimen was taken from the gingival margin of the lower incisors. Slides were stained with hematoxylin and eosin, as well as by Masson. Computer morphometry was performed using the ImageJ software. Results: In EP, TDT has a moderate positive effect on pathomorphological changes in the gum. The combination of TDT and Soderm®-Forte and, to a greater degree, the combination of TDT, Soderm®-Forte and Cytoflavin® have high therapeutic efficacy, characterized by rapid regeneration of the gum tissues.  Conclusion: The combination of TDT, Soderm®-Forte and Cytoflavin® in EP has a more pronounced therapeutic effect, manifested by early regression of pathological changes and acceleration of tissue regeneration in the gum. Graphical Abstract
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来源期刊
Research Results in Pharmacology
Research Results in Pharmacology Medicine-Pharmacology (medical)
CiteScore
1.50
自引率
0.00%
发文量
32
审稿时长
12 weeks
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