控释帕罗西汀与缓释文拉法辛治疗抑郁症的比较分析

V. Kaul, P. Rai
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引用次数: 0

摘要

背景:抑郁症是精神科门诊常见的疾病。治疗数据表明,调节5-羟色胺能神经传递的药物对抑郁症的治疗是有效的。血清素和肾上腺素再摄取抑制剂也被用于治疗抑郁症。本研究旨在比较选择性血清素再摄取抑制剂(帕罗西汀)与血清素和肾上腺素再摄取抑制剂的结果(文拉法辛)。控释帕罗西汀与缓释文拉法辛治疗尼泊尔东部抑郁症疗效的比较分析。材料与方法:前瞻性、开放性、随机对照。连续100名在诺贝尔医学院和教学医院精神科门诊就诊并被诊断为抑郁症的患者被分为两组:第一组也称为帕罗西汀组,第二组称为文拉法辛组。在遵循所有要求的方案(包括Montgomery-Asberg评分量表)后,100名患者被纳入研究,并在第0天、第1周、第2、3、4、6、8记录数据。结果:根据Montgomery-Asberg评分量表在基线和研究完成8周后的评分分析,帕罗西汀控释和文拉法辛缓释治疗的患者改善情况相似。但是,文拉法辛治疗的患者中有许多人出现恶心和便秘(p<0.05)。结论:控制释放的帕罗西汀患者耐受性较好,但两种药物(帕罗西汀和文拉法辛)治疗抑郁症的疗效相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Analysis between Controlled Release Paroxetine and Extended-Release Venlafaxine for Treatment of Depression
Backgroud: Depression is a common condition seen in Psychiatry outpatient department. The treatment data suggest that the drugs that modulate the serotonergic neurotransmission are effective in the treatment of depression. Serotonin and nor Epinephrine re uptake inhibitors are also being used to treat depression. This study is aimed at comparing the results of a selective serotonin re-Uptake inhibitor (Paroxetine) to that of both Serotonin and Nor-Adrenaline re-Uptake inhibitor (Venlafaxine). Comparative analysis between the effects of Controlled release Paroxetine and extended-release Venlafaxine for treatment of depression in eastern Nepal. Materials and Methods: It is a prospective, open and randomized comparison. One Hundred consecutive patients who attended the Psychiatry outpatient door of Nobel Medical College and Teaching Hospital and diagnosed as Depression were enrolled for this study after being divided into 2 groups: Group 1 also being named as Paroxetine group while Group 2 as Venelafaxine group. The 100 patients were enrolled after being followed all the required protocols including Montgomery Asberg rating Scale readings and data were recorded on Day 0, Week 1, 2,3,4,6,8. Results: According to the analysis of the Montgomery Asberg rating Scale scores at baseline and after completion of study at 8weeks, both Paroxetine Controlled Release and Venlafaxine Extended-release treated patients improved similarly. But, many of the Venlafaxine-treated patients had nausea and constipation (p<0.05). Conclusion: Paroxetine controlled released is better tolerated by patient though, the efficacy of both the drugs (paroxetine and venlafaxine) is similar for the treatment of Depression.
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