在作物工程中识别和使用专门代谢物的简易性和复杂性

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Anna Jo Muhich, Amanda Agosto-Ramos, D. Kliebenstein
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引用次数: 4

摘要

植物产生多种具有不同生物活性和潜在应用的特化代谢物。尽管有这种潜力,大多数控制专门代谢物生产的生物合成途径在整个植物界仍未得到解决。遗传学和生化工具的快速发展提高了我们识别植物特化代谢途径的能力。转基因技术和合成生物学方法的进一步发展已经将这种愿望扩展到设计新的途径或将现有途径转移到新的系统中,以解决作物系统中长期存在的困难。这包括提高非生物和生物抗逆性,提高营养成分等。在这篇综述中,我们评估了以下方面的潜力和局限性:(1)利用多组学工具识别植物的特殊代谢途径;(2)在合成生物学或作物工程中使用这些酶。这些主题的目标是强调可能需要进一步投资的研究领域,以加强合成生物学在开发无数专门代谢途径方面的成功应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The ease and complexity of identifying and using specialized metabolites for crop engineering
Plants produce a broad variety of specialized metabolites with distinct biological activities and potential applications. Despite this potential, most biosynthetic pathways governing specialized metabolite production remain largely unresolved across the plant kingdom. The rapid advancement of genetics and biochemical tools has enhanced our ability to identify plant specialized metabolic pathways. Further advancements in transgenic technology and synthetic biology approaches have extended this to a desire to design new pathways or move existing pathways into new systems to address long-running difficulties in crop systems. This includes improving abiotic and biotic stress resistance, boosting nutritional content, etc. In this review, we assess the potential and limitations for (1) identifying specialized metabolic pathways in plants with multi-omics tools and (2) using these enzymes in synthetic biology or crop engineering. The goal of these topics is to highlight areas of research that may need further investment to enhance the successful application of synthetic biology for exploiting the myriad of specialized metabolic pathways.
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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
94
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