原发性脑肿瘤患者手术前后共病性精神障碍的评价

Q3 Medicine

Neurology Psychiatry and Brain Research Pub Date : 2020-06-01 DOI:10.1016/j.npbr.2020.02.003

Robabeh Farzaneh , Ayyoub Malek , Farhad Mirzaei , Shahrokh Amiri , Firooz Salehpour , Ali Meshkini , Zahra Musavi , Sara Farhang , Saeed Dastgiri , Ali Farzane , Fatemeh Ghanbari

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引用次数: 4

摘要

一系列精神疾病与脑肿瘤有关。本研究的目的是评估原发性脑肿瘤患者手术前后精神障碍的频率。方法对120例年龄≥18岁的原发性脑肿瘤成年患者进行研究。纳入了2016年12月至2017年11月期间在大不里士伊玛目礼萨医院住院的近期确诊(不到6个月)患者。诊断访谈是根据DSM-IV标准进行的，在手术前和手术后一个月使用scid - 1进行半结构化访谈。然后比较手术前后患者出现精神疾病的频率。结果26.66%的原发性脑肿瘤患者术前有精神障碍症状。患者中最常见的障碍是抑郁症(13.07%)、适应障碍(9/ 15%)和焦虑症(5.88%)。术后评估显示精神疾病的发生率降低到22.5%。然而，术前和术后结果没有显著差异。在精神障碍患者中，脑肿瘤最常见的部位是额叶，最常见的病理是脑膜瘤。进一步的分析还表明，肿瘤的位置和病理与精神疾病的发病率和类型无关。结论成人原发性脑肿瘤患者最常见的精神障碍为抑郁症。

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Evaluation of comorbid psychiatric disorders in patients with primary brain tumors before and after surgery

Background

A range of psychiatric disorders are associated with brain tumors. The aim of this study was to assess the frequency of psychiatric disorders in adults with primary brain tumors before and after surgery.

Methods

The study was conducted on 120 adult patients diagnosed with primary brain tumors (age ≥18 years). Patients with recent diagnosis (less than 6 months) who were hospitalized in Imam Reza Hospital of Tabriz between December 2016 and November 2017 were included. The diagnostic interview was performed based on DSM-IV criteria using a semi-structured interview with SCID-I before and one month after surgery. The frequency of psychiatric disorders in patients was then compared pre- and post-operation.

Results

Pre-surgical studies revealed that 26.66 % of patients with primary brain tumors had symptoms of psychiatric disorders. The most prevalent disorders found in patients were depressive disorders (13.07 %), adjustment disorder (9/15 %) and anxiety disorders (5.88 %).

Post-surgical evaluations indicated that the frequency of psychiatric disorders was reduced to 22.5 %. However, there was no significant difference between pre- and post-surgical outcomes. Among patients with psychiatric disorders, the most common location of brain tumors was frontal lobe and the most common pathology was meningioma. Further analysis also revealed that tumor location and pathology was not associated with the incidence and type of psychiatric disorders.

Conclusion

In adults with primary brain tumors, the most common psychiatric disorder was depressive disorder.

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来源期刊

Neurology Psychiatry and Brain Research 医学-精神病学

自引率

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期刊介绍： Neurology, Psychiatry & Brain Research publishes original papers and reviews in biological psychiatry, brain research, neurology, neuropsychiatry, neuropsychoimmunology, psychopathology, psychotherapy. The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version. Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.