How to handle a manuscript rejection?

Biomedical researchers desire recognition of their scientific work as a publication in a reputed journal. On the other hand, editors who intend to bring quality work to their readers scrutinize the manuscripts through many checks and peer-review processes. Hence, manuscript rejection is a common phenomenon, and every researcher will have to experience it in their academic career. The manuscript could be rejected at the editor's desk level without peer review or after peer review by experts in the field. Understanding the common reasons for rejection at various levels would help to approach manuscript rejection effectively. The present article aims to provide an overview of the manuscript evaluation process and tips for handling manuscript rejection effectively so that the research work is eventually published.