多羟基化合物对慢性胆囊炎患者的抗炎和保肝作用

Q4 Biochemistry, Genetics and Molecular Biology

Ukrainian Biochemical Journal Pub Date : 2020-09-10 DOI:10.15407/ubj92.04.077

M. Gahramanova, I. Khalilova, A. Omarov, Y. Susak, M. Rudyk, L. Skivka

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引用次数: 1

摘要

中药制剂广泛应用于包括肝胆疾病在内的炎症性疾病的辅助治疗，其中慢性胆囊炎是最常见的一种。本研究旨在探讨由八种药用植物(蜡菊、薄荷、金盏花、蒲公英、黄花蓼、甘菊、马齿苋、贯叶连翘)组成的复方草药水提物对慢性胆囊炎患者生化、血液学指标及免疫反应性指标的影响。结果发现，饮用多凉茶45天后，肝脏生化指标(血清胆固醇水平、丙氨酸转氨酶和天冬氨酸转氨酶活性、总胆红素和非结合胆红素水平)恢复正常，血液学白细胞减少。肝胆疾病患者的红细胞沉降率和中性粒细胞与淋巴细胞比值升高)和免疫(血清促炎细胞因子水平升高)全身性炎症体征。研究结果表明，所研究的多球组合物可推荐作为慢性胆囊炎患者补充治疗的一个组成部分。

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Anti-inflammatory and hepatoprotective effects of polyherbal composition in patients with chronic cholecystitis

Herbal preparations are widely used in the complementary treatment of inflammatory diseases including hepatobiliary disorders, among which chronic cholecystitis is one of the most common. This study was aimed to investigate the effect of the water extract from polyherbal composition consisting of eight medicinal plants (Helichrysum arenarium, Mentha piperita, Calendula officinalis, Taraxacum officinale, Polygonum aviculare, Matricaria chamomilla, Portulaca oleracea, hypericum perforatum) on biochemical and haematologic indices as well as on immune reactivity parameters in patients with chronic cholecystitis. It was found that consumption of polyherbal tea during 45 days was followed by normalization of liver biochemical indices (serum level of cholesterol, alanine aminotransferase and aspartate aminotransferase activity, total and unconjugated bilirubin levels and diminution of hematological (leukocytosis, increased erythrocyte sedimentation rate and neutrophil-to-lymphocyte ratio) and immunological (increased serum level of pro-inflammatory cytokines) signs of systemic inflammation in patients with hepatobiliary disorder. The results of the research showed that the studied polygerbal composition can be recommended as a component of the complementary therapy for patients with chronic cholecystitis.

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来源期刊

Ukrainian Biochemical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The Ukrainian Biochemical Journal publishes original research papers, reviews and brief notes; papers on research methods and techniques; articles on the history of biochemistry, its development and prominent figures; discussion articles; book reviews; chronicles; etc. The journal scope includes not only biochemistry but also related sciences, such as cellular and molecular biology, bioorganic chemistry, biophysics, pharmacology, genetics, and medicine (medical biochemistry et al.) – insofar as the studies use biochemical methods and discuss biochemical findings.