肿瘤坏死因子-α与早产儿视网膜病变的关系

Q4 Medicine

中华眼底病杂志 Pub Date : 2020-03-25 DOI:10.3760/CMA.J.CN511434-20180408-00106

Zhenquan Wu, Lei Zheng, Jian Zeng

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引用次数: 0

摘要

早产儿视网膜病变(ROP)的确切病理生理机制尚不清楚。ROP的危险因素包括过量氧疗、营养不良、感染和炎症。在上述因素中，炎症对ROP的影响受到了较多的关注。TNF-α是一种生物活性蛋白，参与新生血管和炎症。它可能在ROP的发展中发挥作用。本文就近年来TNF-α与ROP关系的研究进行综述，以期为进一步研究ROP的发病机制及治疗方法提供新的思路。关键词:早产儿视网膜病变/病因;肿瘤坏死因子;审查

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Relationship between tumor necrosis factor-α and retinopathy of prematurity

The exact pathophysiological mechanisms of retinopathy of prematurity (ROP) remain elusive. The risk factors of ROP include excessive oxygen therapy, malnutrition, infection and inflammation. Among the factors above, the effect of inflammation on ROP has received more attention. TNF-α is a biological active protein which is involved in neovascularization and inflammation. It may play a role in the development of ROP. This review summarized the studies on the association between TNF-α and ROP in recent years, so as to provide a new way to further study the pathogenesis and treatment methods of ROP. Key words: Retinopathy of prematurity/etiology; Tumor necrosis factor-alpha; Review

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).