生姜提取物和生姜纳米粒子对对对乙酰氨基酚肝毒性和肾毒性的保护作用

IF 3.8 3区农林科学 Q1 VETERINARY SCIENCES

Pakistan Veterinary Journal Pub Date : 2019-10-01 DOI:10.29261/pakvetj/2019.060

Alaa F. Bakr

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引用次数: 20

摘要

收稿日期:修订日期:接受日期:在线发布日期:2018年11月28日2019年3月30日2019年4月06日2019年4月23日对乙酰氨基酚是世界范围内广泛使用的镇痛药。然而，肝毒性和肾毒性是对乙酰氨基酚过量的最大特征。生姜是一种具有抗肿瘤、抗细胞凋亡、抗氧化活性的药用植物。最近，生姜纳米颗粒在肝脏保护中对酒精引起的肝损伤和治疗肠结肠炎进行了研究。本实验旨在从组织学和生化方面判断生姜纳米颗粒相对于生姜提取物在120 mg/kg剂量下对375 mg/kg (1/10 LD50)剂量连续3个月对雄性大鼠的对乙酰氨基酚毒性的保护作用。测定血清丙氨酸转氨酶和天冬氨酸转氨酶。此外，测定血清尿素和尿酸水平。此外，通过测定丙二醛含量和过氧化氢酶活性来评估氧化应激。同时观察肝、肾组织病理变化。本研究表明，生姜提取物对大鼠肝肾生化指标、氧化应激及组织病理结构均有改善作用。然而，GNPs处理的大鼠相对于生姜提取物预处理的大鼠更具保护作用。©2019 PVJ。版权所有

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Assessment of Ginger Extract and Ginger Nanoparticles Protective Activity against Acetaminophen-Induced Hepatotoxicity and Nephrotoxicity in Rats

Received: Revised: Accepted: Published online: November 28, 2018 March 30, 2019 April 06, 2019 April 23, 2019 Acetaminophen is widely used analgesics all over the world. However, hepatotoxicity and nephrotoxicity are the most features of acetaminophen overdose. Ginger is a medicinal plant that has anti-tumorigenic, anti-apoptotic, anti-oxidant activities. Recently, ginger nanoparticles have been investigated in liver protection against alcohol-induced liver damage and in treatment of bowel colitis. Our experiment was aimed to judge the protective activity of ginger nanoparticles relative to ginger extract at dose of 120 mg/kg against acetaminophen toxicity at dose of 375 mg/kg (1/10 LD50) daily for three months in male rats from the histological and biochemical aspects. Serum Alanine aminotransferase and aspartate aminotransferase were determined. In addition, urea and uric acid levels were evaluated in serum. Moreover, oxidative stress was evaluated by determining malondialdehyde content and catalase enzyme activity. Meanwhile, histopathological changes in liver and kidney tissues were observed. The present study indicates that liver and kidney biochemical markers, oxidative stress and histopathological structure are improved in rat pretreated with ginger extract. However, rats treated with GNPs were more protective relative to ginger extract pre-treated rat. ©2019 PVJ. All rights reserved

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来源期刊

Pakistan Veterinary Journal 兽医-兽医学

CiteScore

4.20

自引率

13.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Pakistan Veterinary Journal (Pak Vet J), a quarterly publication, is being published regularly since 1981 by the Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan. It publishes original research manuscripts and review articles on health and diseases of animals including its various aspects like pathology, microbiology, pharmacology, parasitology and its treatment. The “Pak Vet J” (www.pvj.com.pk) is included in Science Citation Index Expended and has got 1.217 impact factor in JCR 2017. Among Veterinary Science Journals of the world (136), “Pak Vet J” has been i) ranked at 75th position and ii) placed Q2 in Quartile in Category. The journal is read, abstracted and indexed internationally.