褐藻(褐藻科,双叶藻科)硫酸酸化多糖的抗炎活性

ereen naeem, A. El-ghoneimy, H. Ahmed
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引用次数: 1

摘要

DOI: 10.21608/svu.2022.105385.1158收稿日期:2021年11月16日收稿日期:2022年3月20日出版日期:2022年3月30日*通讯作者:eeen Kondos Naeem E-mail: ereenkondos@yahoo.com引用本文:Kondos et al.,棕藻Padina boergesenii (Phaeophyceae, dictyotacae)硫酸酸化多糖的抗炎活性研究SVU-IJVS 2022, 5(1): 83-101。版权所有:©Kondos et al。这是一篇在creative common attribution许可条款下发布的开放获取文章,该许可允许在任何媒体上不受限制地使用、分发和复制,前提是创建原作者和来源。竞争利益:作者声明不存在竞争利益。褐藻(BA)作为一种有益的药理活性成分的来源,近年来引起了人们的高度关注。随后,BA水溶性多糖因其抗肿瘤和抗氧化活性引起了国内外研究者的关注。本研究对棕藻巴底纳(Padina boergesenii)多糖提取物的抗炎活性进行了评价。本研究采用二甲苯致耳炎症模型和卡拉胶致足水肿模型。分别对75、125、250、500、750、1000 mg/kg的PLS剂量进行了试验。我们获得的数据显示,PLS以剂量依赖的方式抑制两种模型的炎症反应。有趣的是,PLS的抗炎作用与降低一氧化氮和MDA自由基以及促炎细胞因子:il - 1β、IL-6和TNF-α水平有关。这一数据突出了分离的PLS的治疗意义。与抗炎药双氯芬酸相比,这种多糖具有较高的抗炎活性,因此这种天然化合物可以作为治疗炎症的有效药物推荐使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae)
DOI: 10.21608/svu.2022.105385.1158 Received: November 16, 2021 Accepted: March 20, 2022 Published: March 30, 2022 *Corresponding Author: Ereen Kondos Naeem E-mail: ereenkondos@yahoo.com Citation: Kondos et al., Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae) SVU-IJVS 2022, 5(1): 83-101. Copyright: © Kondos et al. This is an open access article distributed under the terms of the creative common attribution license, which permits unrestricted use, distribution and reproduction in any medium provided the original author and source are created. Competing interest: The authors have declared that no competing interest exists. Abstract Brown algae (BA) have recently gained high interest as a beneficial source of pharmacological numerous invaluable active constituents. Subsequently, water-soluble polysaccharides of BA attracted the attention of researchers worldwide due to their anticancer and antioxidant activities. This study was carried out to evaluate the anti-inflammatory activity of polysaccharides (PLS) extract of Padina boergesenii brown algae. Xylene produced-ear inflammation and carrageenan produced-paw edema models were used in this study. The PLS doses of 75, 125, 250, 500, 750, 1000 mg/kg were tested. Our obtained data revealed that PLS inhibited the inflammatory reactions of both models in a dose-dependent manner. Interestingly, the anti-inflammatory effect of PLS is associated with lowering of nitric oxide and MDA free radicals and pro-inflammatory cytokines: IL1β, IL-6, and TNF-α level. This data highlights the therapeutic significance of isolated PLS. As this polysaccharide possesses high anti-inflammatory activity in comparison to the anti-inflammatory drug diclofenac, therefore this natural compound could be recommended as an effective remedy for inflammation.
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