伊维菌素对绵羊细胞因子和免疫球蛋白水平的影响

IF 0.2 4区农林科学 Q4 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Revista Colombiana De Ciencias Pecuarias Pub Date : 2023-07-12 DOI:10.17533/udea.rccp.v36n4a5

R. Canbar, I. Dik, Muhittin Uslu, M. Ider, M. Arslan, E. Yazar

{"title":"伊维菌素对绵羊细胞因子和免疫球蛋白水平的影响","authors":"R. Canbar, I. Dik, Muhittin Uslu, M. Ider, M. Arslan, E. Yazar","doi":"10.17533/udea.rccp.v36n4a5","DOIUrl":null,"url":null,"abstract":"32 Backgroud: Ivermectin may changes the levels of cytokines and immunoglobulins in sheep, 33 considering that avermectins affect the immune system. Objective: To determine the effect of 34 ivermectin on the cytokines and immunoglobulins in sheep. Methods: After administration of 35 ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-36 2, interleukin-6, and interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin 37 E levels were measured with ELISA reader. Results: Statistically significant (p<0.05) fluctuations 38 were detected in interkeukin-2 and interkeukin-10 levels. Transient increases (p<0.05) were 39 measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: 40 Ivermectin may affect immune system parameters in healthy sheep, however, the effects of 41 ivermectin administration on infected sheep should be investigated.","PeriodicalId":49613,"journal":{"name":"Revista Colombiana De Ciencias Pecuarias","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of ivermectin on cytokine and immunoglobulin levels in sheep\",\"authors\":\"R. Canbar, I. Dik, Muhittin Uslu, M. Ider, M. Arslan, E. Yazar\",\"doi\":\"10.17533/udea.rccp.v36n4a5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"32 Backgroud: Ivermectin may changes the levels of cytokines and immunoglobulins in sheep, 33 considering that avermectins affect the immune system. Objective: To determine the effect of 34 ivermectin on the cytokines and immunoglobulins in sheep. Methods: After administration of 35 ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-36 2, interleukin-6, and interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin 37 E levels were measured with ELISA reader. Results: Statistically significant (p<0.05) fluctuations 38 were detected in interkeukin-2 and interkeukin-10 levels. Transient increases (p<0.05) were 39 measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: 40 Ivermectin may affect immune system parameters in healthy sheep, however, the effects of 41 ivermectin administration on infected sheep should be investigated.\",\"PeriodicalId\":49613,\"journal\":{\"name\":\"Revista Colombiana De Ciencias Pecuarias\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Colombiana De Ciencias Pecuarias\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.17533/udea.rccp.v36n4a5\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Colombiana De Ciencias Pecuarias","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.17533/udea.rccp.v36n4a5","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}

引用次数: 0

摘要

32背景：伊维菌素可能会改变绵羊的细胞因子和免疫球蛋白水平，33考虑到阿维菌素会影响免疫系统。目的：观察34伊维菌素对绵羊细胞因子和免疫球蛋白的影响。方法：用ELISA法测定10只健康绵羊给予35只伊维菌素后，绵羊特异性干扰素-α、肿瘤坏死因子-α、白细胞介素-36 2、白细胞白细胞介素6和白细胞介质-10、免疫球蛋白G、免疫球素M和免疫球蛋白37E的水平。结果：白细胞介素-2和白细胞介蛋白-10水平有统计学意义（p＜0.05）的波动38。肿瘤坏死因子-α和免疫球蛋白E水平的瞬时升高（p＜0.05）。结论：40伊维菌素可能影响健康绵羊的免疫系统参数，但应研究41伊维菌素对感染绵羊的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effects of ivermectin on cytokine and immunoglobulin levels in sheep

32 Backgroud: Ivermectin may changes the levels of cytokines and immunoglobulins in sheep, 33 considering that avermectins affect the immune system. Objective: To determine the effect of 34 ivermectin on the cytokines and immunoglobulins in sheep. Methods: After administration of 35 ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-36 2, interleukin-6, and interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin 37 E levels were measured with ELISA reader. Results: Statistically significant (p<0.05) fluctuations 38 were detected in interkeukin-2 and interkeukin-10 levels. Transient increases (p<0.05) were 39 measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: 40 Ivermectin may affect immune system parameters in healthy sheep, however, the effects of 41 ivermectin administration on infected sheep should be investigated.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Revista Colombiana De Ciencias Pecuarias AGRICULTURE, DAIRY & ANIMAL SCIENCE-

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The editors of Revista Colombiana de Ciencias Pecuarias (RCCP) welcome the submission of original manuscripts on experimental and clinical studies associated with the broad areas of animal sciences and veterinary medicine as they interface with biochemistry, molecular biology, physiology, pharmacology, toxicology, pathology, microbiology, parasitology, immunology and epidemiology. The scope of the journal includes studies of basic and applied research in animal management and production, feeding and nutrition, reproduction, breeding, genetics, animal welfare and behavior; as well as animal production focussed from biotechnology, soil science, agrostology, silvopastoral systems, livestock economics and the environment. The criteria for acceptance of papers submitted for publication are originality, quality and clarity of the content. Each contribution must be based on original, unpublished research that has not been simultaneously submitted to other journals. All papers will be peer reviewed. All authors bear responsibility for ensuring the integrity and quality of their reported research. It is the author''s responsibility to secure permission to use figures or tables that have been published elsewhere. Contributions may be classified as original research, review, rapid communication, clinical case studies or methodological articles, as well as news/commentaries or letters to the editor. Most review articles are invited by the editor. Authors interested in submitting a review article should contact the corresponding editor. Rapid publication of original manuscripts is a goal of the journal. Manuscripts must be written in English. Each manuscript is considered for publication with the understanding that it has not been simultaneously submitted to any other journal. Upon acceptance for publication, papers are subject to editorial review and revision.