超声辅助下由d-核糖合成甲基2,3- o -异丙基-β- d-核呋喃苷及其制备新型1,2,3-三唑糖缀合物的研究

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Carbohydrate Chemistry Pub Date : 2021-01-01 DOI:10.1080/07328303.2021.1990942

Tereza Cristina Santos Evangelista , Gabriel Alves Souto de Aquino , Marcio Roberto H. Donza , Rafael Lisboa Leitão , Victor Salarolli de Carvalho , Carlos Roland Kaiser , Sabrina Baptista Ferreira

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引用次数: 0

摘要

描述了用超声辐照将d -核糖转化为其2,3- o -异丙基衍生物的过程。事实证明，超声波作为反应的能量来源是一个很好的选择。研究了不同的反应时间，在不需要提纯丙酮的情况下获得了较短的反应时间和较高的收率。然后将该化合物用作合成以不同方式连接在一起的1,2,3-三唑的23种新糖缀合物的起始材料。合成的化合物通过FTIR、1H NMR、13C NMR和HRMS等技术进行了表征。下载:下载高分辨率图片(132KB)下载:下载全尺寸图片

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A facile ultrasound-assisted synthesis of methyl 2,3-O-isopropylidene-β-D-ribofuranoside from D-ribose and its use to prepare new 1,2,3-triazole glycoconjugates

The conversion of D-ribose into its 2,3-O-isopropylidene derivative using ultrasonic irradiation is described. The ultrasound proved to be an excellent alternative as the energy source for the reaction. Different reaction times were investigated, and shorter reaction times and high yield were achieved without the need for purification of the acetonide. The compound was then applied as the starting material in the synthesis of 23 new glycoconjugates of 1,2,3-triazole that are tethered together in different ways. The synthesized compounds were characterized by FTIR, ¹H NMR, ¹³C NMR, and HRMS techniques.

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.