传统和先进的神经影像学对综合医疗中心中枢神经系统淋巴瘤患者的诊断和鉴别诊断的贡献

Q4 Medicine
Ali M. El Dirani, Zahraa Hachem, A. Mohanna, A. Zaylaa
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引用次数: 0

摘要

中枢神经系统淋巴瘤,特别是原发性中枢神经系统淋巴瘤的诊断是基于大脑成像进行的,从而避免了不必要的手术扩展。但传统的成像技术,如计算机断层扫描和磁共振成像,并不令人满意。本研究旨在表征高级神经成像的频谱,如黎巴嫩一家综合医疗中心中枢神经系统淋巴瘤患者的高级磁共振成像特征,并将其与文献综述中描述的进行比较。这是一项对10岁以上急诊科和放射科患者的临床数据和影像学特征的回顾性探索性研究,这些患者在组织病理学上被诊断为颅内淋巴瘤。这项研究可能是第一次对9年以上的当地患者群体进行中枢神经系统淋巴瘤的放射学评估。结果显示,对10名免疫活性中枢神经系统淋巴瘤患者的计算机断层扫描和磁共振成像数据的研究与先前描述的患者群体一致,但性别参数除外。肿瘤大多出现在第五或第六个十年,它们可能是孤立的或多灶的。损伤通常是在2020年5月14日提交给《开放神经影像学杂志》的预印本中位于幕上隔室。在大脑计算机断层扫描上,病变是高密度的,在对比前磁共振图像中,病变在T1上表现为低强度,在T2加权图像上表现为高强度,但在灰质方面表现为低密度。与其他颅内肿瘤(如胶质母细胞瘤)相比,病变周围也有轻度至中度水肿。评估结果显示,在对比度后的磁共振图像上,大多数病变表现出50%的均匀增强。大多数病变也表现出不太常见的不均匀环状增强40%,而罕见的无增强10%。钙化、出血和坏死是罕见的表现,仅在一名患者中出现。作为未来的展望,研究先进的成像技术是否不仅可以提供非侵入性和形态学特征,还可以提供非侵袭性的生物学特征,从而可以考虑准确的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Traditional and Advanced Neuroimaging Contributions to the Diagnosis and Differential Diagnosis of Central Nervous System Lymphoma Patients Visiting a Comprehensive Medical Center
The diagnosis of Central Nervous System Lymphoma, especially the Primary Central Nervous System Lymphoma is carried out based on brain imaging, thus avoiding an unnecessary extend of surgery. But the traditional imaging techniques, such as Computed Tomography and Magnetic Resonance Imaging, were not satisfactory. This study was conducted to characterize the spectrum of advanced Neuroimaging, such as the advanced Magnetic Resonance Imaging features in the Central Nervous System Lymphoma patients in a comprehensive medical center in Lebanon, and compare them to what has been described in the literature review. It is a retrospective exploratory study of the clinical data and imaging features for patients admitted to the emergency and radiology departments with ages above 10 years, and who were diagnosed histopathologically with intracranial lymphoma. This study may be the first to make a Radiological evaluation of Central Nervous System Lymphoma on the local population of patients over 9 years . Results showed that the study of the Computed Tomography and Magnetic Resonance Imaging data of 10 immunocompetent patients with Central Nervous System Lymphoma concurs with the previously described patient populations, except for the gender parameter. Tumors were mostly presented in the fifth or Sixth decade and they could be solitary or multi-focal. Lesions were typically located Preprint submitted to The Open Neuroimaging Journal May 14, 2020 in the supratentorial compartment. On the brain Computed Tomography, the lesions were hyperdense, and in pre-contrast Magnetic Resonance images, the lesions appeared hypointense on T1 and hyperintense on T2-Weighted images, but hypointense with respect to the grey matter. The lesions were also surrounded with a mild to moderate edema as compared to other intracranial neoplasms, such as glioblastomas. Evaluation results showed that on post-contrast Magnetic Resonance images, the majority of lesions exhibited a homogeneous enhancement of 50%. Majority of the lesions also showed a less common heterogeneous ring-like enhancement of 40%, and revealed the uncommon absence of enhancement of 10%. Calcifications, hemorrhage, and necrosis were rare findings and were present in only one patient. As a future prospect, studying whether the advanced imaging techniques may provide not only non-invasive and morphological characteristics but also non-invasive biological characteristics and thus accurate diagnosis could be considered.
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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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