{"title":"雌激素拮抗剂和抗雄激素能预防新冠肺炎的肺部受累吗？","authors":"M. Jalalian","doi":"10.19082/7681","DOIUrl":null,"url":null,"abstract":"Male and female hormones are upregolators of expression of Angiotensin-converting Enzyme 2 (ACE2) gene. This short article proposes a hypothesis about the potential effect of estrogen antagonists and anti-androgens in preventing pulmonary involvement in COVID-19 infection through their downregulatory effect on ACE2 expression.","PeriodicalId":11603,"journal":{"name":"Electronic Physician","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Do estrogen antagonists and anti-androgens prevent the COVID-19’s pulmonary involvement?\",\"authors\":\"M. Jalalian\",\"doi\":\"10.19082/7681\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Male and female hormones are upregolators of expression of Angiotensin-converting Enzyme 2 (ACE2) gene. This short article proposes a hypothesis about the potential effect of estrogen antagonists and anti-androgens in preventing pulmonary involvement in COVID-19 infection through their downregulatory effect on ACE2 expression.\",\"PeriodicalId\":11603,\"journal\":{\"name\":\"Electronic Physician\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Electronic Physician\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.19082/7681\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electronic Physician","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19082/7681","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Do estrogen antagonists and anti-androgens prevent the COVID-19’s pulmonary involvement?
Male and female hormones are upregolators of expression of Angiotensin-converting Enzyme 2 (ACE2) gene. This short article proposes a hypothesis about the potential effect of estrogen antagonists and anti-androgens in preventing pulmonary involvement in COVID-19 infection through their downregulatory effect on ACE2 expression.
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