果蝇胰岛素和脂肪动力学激素/胰高血糖素产生的调控

Q1 Biochemistry, Genetics and Molecular Biology

Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2019-08-04 DOI:10.1002/wdev.360

Muhammad Ahmad, Li He, N. Perrimon

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引用次数: 40

摘要

代谢稳态是在各种类群的体液因子的严格调控下进行的。特别是胰岛素和胰高血糖素，在果蝇中分别被称为果蝇胰岛素样肽(DILPs)和脂肪动力学激素(AKH)，是调节大多数后生动物代谢的关键激素。虽然我们对dilp的调节了解很多，但对AKH/胰高血糖素产生的调节机制仍然知之甚少。在这篇综述中，我们描述了调节dilp和AKH产生的各种因素，并强调需要未来的研究来解释果蝇是如何控制能量稳态的。

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Regulation of insulin and adipokinetic hormone/glucagon production in flies

Metabolic homeostasis is under strict regulation of humoral factors across various taxa. In particular, insulin and glucagon, referred to in Drosophila as Drosophila insulin‐like peptides (DILPs) and adipokinetic hormone (AKH), respectively, are key hormones that regulate metabolism in most metazoa. While much is known about the regulation of DILPs, the mechanisms regulating AKH/glucagon production is still poorly understood. In this review, we describe the various factors that regulate the production of DILPs and AKH and emphasize the need for future studies to decipher how energy homeostasis is governed in Drosophila.

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来源期刊

Wiley Interdisciplinary Reviews: Developmental Biology DEVELOPMENTAL BIOLOGY-

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期刊介绍： Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.