线粒体通路在肝缺血再灌注损伤中的作用

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2020-01-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2020.01.018

Jie Lin, Z. Zeng

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引用次数: 0

摘要

肝缺血再灌注损伤是肝胆外科手术中常见的损伤，与术后肝功能恢复及预后密切相关。虽然肝缺血再灌注损伤的机制复杂，但线粒体结构功能障碍是肝缺血再灌注损伤的重要事件。本文综述了肝脏缺血再灌注损伤的机制，重点介绍了通过线粒体自噬和细胞凋亡途径减轻肝脏缺血再灌注损伤的机制。关键词:再灌注损伤;肝;线粒体

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Effect of mitochondrial pathway on hepatic ischemia-reperfusion injury

Hepatic ischemia-reperfusion injury is often occurred during the hepatobiliary surgery, and is closely correlated with postoperative of liver function recovery and prognosis. Although the mechanisms of hepatic ischemia-reperfusion injury are complex, mitochondrial structural dysfunction is an important event for hepatic ischemia-reperfusion injury. This review summarized the current mechanism of hepatic ischemia-reperfusion injury, and with a focus on mitigating its damage through the mitochondrial autophagy and apoptosis pathway. Key words: Reperfusion injury; Liver; Mitochondria

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来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.