抗抑郁药对谷胱甘肽S-转移酶和丁酰胆碱酯酶的抑制作用——酶与药物相互作用综述

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2022-04-28 DOI:10.2174/1573408018666220428100417

Victor Markus, Özlem Dalmızrak, K. Teralı, N. Özer

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引用次数: 0

摘要

细胞酶防御屏障的破坏会增加接触亲电试剂的持续时间及其可能产生的毒性的严重程度。在这篇小型综述中，我们讨论了世界各地常用的不同抗抑郁药以及用于各种形式抑郁症的草药产品对酶防御系统的抑制作用。我们的工作主要集中在两个重要的生物转化酶系统，即谷胱甘肽S-转移酶和胆碱酯酶，与三环类抗抑郁药（TCAs）、选择性血清素再摄取抑制剂（SSRIs）和金丝桃素的相互作用上。本文深入讨论了现有已发表研究的结果及其对健康和疾病的影响。

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The Inhibition of Glutathione S-Transferases and Butyrylcholinesterase by Antidepressants: A Mini-Review on Enzyme-Drug Interaction

Compromises in the cellular enzymatic defense barrier can increase the duration of exposure to electrophiles and the severity of toxicity they may incur. In this mini-review, we discuss the inhibition of the enzymatic defense systems by different antidepressants commonly prescribed worldwide as well as herbal products used for various forms of depression. Our work is primarily focused on the interactions of two prominent biotransformation enzyme systems, namely glutathione S-transferases and cholinesterases, with tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and hypericin. The outcomes of available published studies and their implications in health and disease are discussed here in depth.

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来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.