鸡卵刺激后肝脏基因表达和DNA甲基化对肠道微生物谱变化的响应

IF 1.4 4区农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Journal of Animal and Feed Sciences Pub Date : 2023-02-20 DOI:10.22358/jafs/156098/2023

A. Dunisławska, E. Pietrzak, A. Beldowska, A. Sławinska, M. Siwek

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引用次数: 0

摘要

肠道微生物群在肠道和肝脏之间的信号传导中起着重要作用。肠道细菌产生短链脂肪酸和其他影响内部交流的信号分子。肠道微生物群组成的变化可能导致这种交流的改变，最终可能导致表观遗传机制驱动的基因表达的改变。本研究旨在确定卵中递送的生物活性物质对早期微生物组修饰对肠道内容物中细菌相对丰度以及肝脏基因表达和甲基化水平变化的影响。在培养的第12天，益生菌

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Response in liver gene expression and DNA methylation to changes in the intestinal microbial profile after in ovo stimulation of chickens

. The intestinal microbiota plays an important role in the signalling between the gut and the liver. Intestinal bacteria produce short-chain fatty acids and other signalling molecules that affect internal communication. Changes in the composition of the gut microbiota can lead to alternations in this communication, which may ultimately lead to modifications in gene expression driven by epigenetic mechanisms. This study aimed to determine the effect of early microbiome modifications by bioactive substances delivered in ovo on changes in the relative abundance of bacteria in the intestinal contents and the level of expression and methylation of hepatic genes. On day 12 of incubation, a probiotic, a prebiotic

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来源期刊

Journal of Animal and Feed Sciences 农林科学-奶制品与动物科学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Journal of Animal and Feed Sciences (JAFS, J. Anim. Feed Sci.) has been published by the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences in Jabłonna (Poland) since 1991. It is a continuation of the Polish-language journal Roczniki Nauk Rolniczych. Seria B, Zootechniczna published by the Polish Academy of Sciences since 1969. JAFS is an international scientific journal published quarterly, about 40 papers per year including original papers, short communications and occasionally reviews. All papers are peer-reviewed and related to basic and applied researches in the field of animal breeding and genetics, physiology of nutrition, animal feeding, feed technology and food preservation. The journal distinguishes the multidisciplinary nature of physiological and nutritional sciences and so includes papers specialized in all fields connected with animal well-being, including molecular and cell biology and the emerging area of genetics.