{"title":"穴位药物试验作为一种非侵入性诊断工具，用于确定慢性丙型肝炎病毒感染患者的索非布韦日剂量","authors":"Naylya Djumaeva, Gulnara Akhundjanova, Leyla Djumaeva, Dilbar Urunova","doi":"10.1186/s43094-023-00514-z","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Acupuncture points are known for their unique bioelectric properties. Medication testing at acupuncture points has not previously been used to determine the daily doses of sofosbuvir in patients with chronic hepatitis C virus infection.</p><h3>Results</h3><p>This pilot study included 61 patients with a confirmed diagnosis of chronic hepatitis C virus infection. Medicament testing of acupuncture points of the liver meridian (“Xing-jian”) and Voll’s circulation meridian (“Cells and lobules of the liver”) was performed to determine the daily doses of sofosbuvir. A correlation analysis was carried out between the tested doses of the drug and the viral load in the blood of patients to confirm the results of testing the daily doses of sofosbuvir. Patients with chronic hepatitis C virus infection showed a significant positive correlation between tested daily doses of sofosbuvir and viral load in their blood. The mean values of the tested doses of sofosbuvir did not vary at different acupuncture points and significantly differed depending on viral load.</p><h3>Conclusions</h3><p>This study showed that acupuncture points can serve as a diagnostic tool in the process of medicament testing and allow the determination of daily doses of sofosbuvir in patients with chronic hepatitis C virus infection. To further assess the clinical applications and physiological basis of medicament testing methods, additional clinical and instrumental studies are needed with a large sample of patients.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"9 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-023-00514-z","citationCount":"0","resultStr":"{\"title\":\"Medicament testing on acupuncture points as a non-invasive diagnostic tool for determining the daily doses of sofosbuvir in patients with chronic hepatitis C virus infection\",\"authors\":\"Naylya Djumaeva, Gulnara Akhundjanova, Leyla Djumaeva, Dilbar Urunova\",\"doi\":\"10.1186/s43094-023-00514-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Acupuncture points are known for their unique bioelectric properties. Medication testing at acupuncture points has not previously been used to determine the daily doses of sofosbuvir in patients with chronic hepatitis C virus infection.</p><h3>Results</h3><p>This pilot study included 61 patients with a confirmed diagnosis of chronic hepatitis C virus infection. Medicament testing of acupuncture points of the liver meridian (“Xing-jian”) and Voll’s circulation meridian (“Cells and lobules of the liver”) was performed to determine the daily doses of sofosbuvir. A correlation analysis was carried out between the tested doses of the drug and the viral load in the blood of patients to confirm the results of testing the daily doses of sofosbuvir. Patients with chronic hepatitis C virus infection showed a significant positive correlation between tested daily doses of sofosbuvir and viral load in their blood. The mean values of the tested doses of sofosbuvir did not vary at different acupuncture points and significantly differed depending on viral load.</p><h3>Conclusions</h3><p>This study showed that acupuncture points can serve as a diagnostic tool in the process of medicament testing and allow the determination of daily doses of sofosbuvir in patients with chronic hepatitis C virus infection. To further assess the clinical applications and physiological basis of medicament testing methods, additional clinical and instrumental studies are needed with a large sample of patients.</p></div>\",\"PeriodicalId\":577,\"journal\":{\"name\":\"Future Journal of Pharmaceutical Sciences\",\"volume\":\"9 1\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-023-00514-z\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1186/s43094-023-00514-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1186/s43094-023-00514-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Medicament testing on acupuncture points as a non-invasive diagnostic tool for determining the daily doses of sofosbuvir in patients with chronic hepatitis C virus infection
Background
Acupuncture points are known for their unique bioelectric properties. Medication testing at acupuncture points has not previously been used to determine the daily doses of sofosbuvir in patients with chronic hepatitis C virus infection.
Results
This pilot study included 61 patients with a confirmed diagnosis of chronic hepatitis C virus infection. Medicament testing of acupuncture points of the liver meridian (“Xing-jian”) and Voll’s circulation meridian (“Cells and lobules of the liver”) was performed to determine the daily doses of sofosbuvir. A correlation analysis was carried out between the tested doses of the drug and the viral load in the blood of patients to confirm the results of testing the daily doses of sofosbuvir. Patients with chronic hepatitis C virus infection showed a significant positive correlation between tested daily doses of sofosbuvir and viral load in their blood. The mean values of the tested doses of sofosbuvir did not vary at different acupuncture points and significantly differed depending on viral load.
Conclusions
This study showed that acupuncture points can serve as a diagnostic tool in the process of medicament testing and allow the determination of daily doses of sofosbuvir in patients with chronic hepatitis C virus infection. To further assess the clinical applications and physiological basis of medicament testing methods, additional clinical and instrumental studies are needed with a large sample of patients.
期刊介绍：
Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
