壳聚糖保护食管黏膜凝胶的理化性质

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2022-09-30 DOI:10.15259/pcacd.27.013

K. Małolepsza-Jarmołowska

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引用次数: 0

摘要

反流性疾病的发病率随着年龄的增长而增加，不分性别。这种疾病在高度发达的国家诊断得更为常见。除了酸性反流外，碱性肠道内容物排入食道也是一个主要问题。这项研究是为了检查水凝胶是否能防止对食道粘膜的刺激。研究了壳聚糖和羟丙基甲基纤维素对壳聚糖凝胶性能的影响。含有4.0%羟丙基甲基纤维素的制剂显示出最低的pH值。这些凝胶可用于治疗晚期碱性反流。在所有测试的凝胶中添加壳聚糖增加了它们的pH值和动态粘度。质地测试表明羟丙基甲基纤维素浓度对测试凝胶的粘附功的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PHYSICOCHEMICAL PROPERTIES OF GELS WITH CHITOSAN THAT PROTECT THE OESOPHAGEAL MUCOSA

The incidence of reflux disease increases with age, regardless of gender. This disease is diagnosed more often in highly developed countries. In addition to acidic reflux, the discharge of alkaline intestinal contents into the oesophagus is a major problem. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and hydroxypropylmethylcellulose on the properties of chitosan-containing gels. Preparations containing 4.0% hydroxypropylmethylcellulose showed the lowest pH. These gels could be used to treat advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of the hydroxypropylmethylcellulose concentration on the adhesion work of the tested gels.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.