新生儿长期黄疸的隐性原因:维生素B12缺乏

IF 0.3 Q4 PEDIATRICS
Erhan Aygun, O. A. Sayman, E. Erturk, Seda Yılmaz Semerci, M. K. Kanburoglu
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引用次数: 0

摘要

【摘要】目的延长黄疸是指足月婴儿出生后14天和早产儿出生后21天血清胆红素水平超过5 mg/dL。虽然在大多数长期黄疸病例中无法找到根本原因,但这可能是严重问题的第一个迹象。因此,本研究旨在评估维生素B12缺乏与新生儿长期黄疸之间的关系。材料与方法本描述性横断面研究于2015年1月1日至2020年10月1日在某大学医院进行。所有的参与者都是在儿科门诊就诊的婴儿。研究对象为妊娠50 ~ 35周且黄疸持续时间不明的婴儿。对照组为妊娠50 ~ 35周无黄疸延长的婴儿。比较两组患者的人口学、临床特征及血清维生素B12水平。结果共纳入126例婴儿,其中延长期黄疸66例。研究组平均妊娠周为38.4±1.8周,对照组平均妊娠周为38.6±1.9周。在人口统计学和实验室数据方面,两组之间没有差异。研究组的维生素B12水平(中位数= 170 pg/mL)明显低于对照组(中位数= 268 pg/mL)。结论基于本研究结果,维生素B12缺乏被认为是黄疸延长的重要原因,维生素B12缺乏在黄疸延长的病因中所起的作用有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency
Abstract Objective  Prolonged jaundice is defined as a serum bilirubin level of more than 5 mg/dL, which persists at postnatal 14 days in term infants and 21 days following birth in preterm infants. Although the underlying causes cannot be found in the majority of prolonged jaundice cases, this may be the first sign of a serious issue. Therefore, this study aimed to evaluate the association between vitamin B12 deficiency and prolonged jaundice in newborns. Material and Methods  This descriptive cross-sectional study was performed in a university hospital between January 1, 2015 and October 1, 2020. All participants consisted of infants who were admitted to the pediatric outpatient clinics. Infants > 35 weeks of gestation and with prolonged jaundice of unknown etiology were included in the study group. The control group consisted of infants > 35 weeks of gestation without prolonged jaundice. Demographic and clinical characteristics and serum vitamin B12 levels were evaluated comparatively. Results  A total of 126 infants, 66 of whom had prolonged jaundice, were included. The mean gestational week of the study group was 38.4 ± 1.8, and the control group was 38.6 ± 1.9 weeks. There was no difference between the groups in terms of demographics and laboratory data. The vitamin B12 level of the study group was significantly lower (median = 170 pg/mL) than the control (median = 268 pg/mL). Conclusion  Based on the findings of this study, vitamin B12 deficiency was thought to be an important cause of prolonged jaundice, and further studies are needed to explain the role of vitamin B12 deficiency in the etiology of prolonged jaundice.
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CiteScore
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