弥散张量成像在帕金森病诊断中的作用

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2021-04-30 DOI:10.5812/ANS.100174

Elahesadat Hosseini, F. Ashrafi, F. Faeghi, A. Hekmatnia

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引用次数: 0

摘要

背景:帕金森病(PD)是一种影响含多巴胺神经元的慢性进行性神经退行性疾病。本研究探讨了扩散张量成像(Diffusion Tensor imaging, DTI)方法在PD检测中的作用。目的:本研究的目的是利用无创DTI技术研究PD患者脑白质的微结构损伤。方法:对20例PD患者进行综合临床评价和DTI资料分析。同时对10名正常受试者进行调查。分数各向异性(FA)和平均扩散率(MD)值通过绘制感兴趣区域(ROI)在8个不同的大脑区域计算。结果:PD组与健康对照组黑质(SN) FA、MD水平差异有统计学意义。PD组与HC组在膝关节、内囊前肢、脾、壳核等部位的DTI参数也存在差异。结论:综上所述，DTI作为一种无创检测帕金森病的方法是有价值的。

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Role of Diffusion Tensor Imaging in Parkinson's Disease Diagnosis

Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease that affects the dopamine-containing neurons. In this study, the role of the Diffusion Tensor imaging (DTI) method was investigated in the detection of PD. Objectives: The purpose of this study was to investigate the microstructural damage of the brain's white matter in PD using a non-invasive DTI technique. Methods: Twenty patients with PD were studied with comprehensive clinical assessments and DTI data. Also, 10 normal subjects were investigated. Fractional anisotropic (FA) and mean diffusivity (MD) values were calculated by drawing region of interest (ROI) on eight distinctive areas of the brain. Results: The level of FA and MD in substantia nigra (SN) was significantly different between the PD and healthy control (HC) groups. Also, differences were found in DTI parameters between PD and HC groups in some regions, such as genu, anterior limb of internal capsule (ALIC), splenium, and putamen. Conclusions: To summarize, DTI as a non-invasive method can be useful in the detection of Parkinson's disease.

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Archives of Neuroscience NEUROSCIENCES-

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期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.