嗜铬细胞瘤和副神经节瘤的影像学研究进展

IF 1.2

International Journal of Endocrine Oncology Pub Date : 2017-07-07 DOI:10.2217/IJE-2017-0004

D. Taïeb, K. Wolf, K. Pacak

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引用次数: 0

摘要

嗜铬细胞瘤和副神经节瘤（PPGL）属于神经嵴细胞源性肿瘤家族，可广泛分布于全身。在过去的几年里，对于这些肿瘤，精准医学提供了改善患者护理的前景。通过肿瘤可视化和分子特征识别，核医学能够在PPGL精准医学中发挥关键作用。发现68Ga标记的生长抑素类似物可改善头颈部副神经节瘤、SDHx相关PPGLs和转移性PPGLs的检测和分期，而与遗传背景无关。对于与激酶信号增加或HIF2A突变相关的PPGLs，18F-氟二羟基苯丙氨酸似乎是信息量最大的放射性药物。这篇综述强调了与PPGL成像选项相关的当前治疗方法和未来前景。

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Recent advances in the imaging of pheochromocytomas and paragangliomas

Pheochromocytoma and paraganglioma (PPGL) belong to the family of neural crest cell-derived neoplasms, and can be widely distributed throughout the body. Over the past few years, with respect to these tumors, precision medicine has offered the promise of improved patient care. Through tumor visualization and identification of molecular signatures, nuclear medicine is capable of playing a key role in PPGL precision medicine. 68Ga-labeled somatostatin analogs were found to improve the detection and staging of head and neck paragangliomas, SDHx-related PPGLs and metastatic PPGLs regardless of genetic background. For PPGLs associated with increased kinase signaling or HIF2A mutations, 18F-fluorodihydroxyphenylalanine appears to be the most informative radiopharmaceutical. This review emphasizes the current theranostic approaches and future perspective related to PPGL imaging options.

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来源期刊

International Journal of Endocrine Oncology ONCOLOGY-

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Endocrine Oncology is a quarterly, peer-reviewed journal that helps the clinician to keep up to date with best practice in this fast-moving field. The journal highlights significant advances in basic and translational research, and places them in context for future therapy. The journal presents the latest research findings in diagnosis and management of endocrine cancer, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. The journal welcomes the unsolicited submission of article proposals and original research manuscripts.