铜-白蛋白复合物对碘乙酸钠诱导的膝关节骨性关节炎硫酸软骨素改善作用的体内研究

Doaa A. Elnakip, Nashwa A. M. Mostafa, Asmaa A. Metwally, Reham I. El-Mahdy, A. Nassar, Obeid Shanab, K. Ghareeb, A. Abdeen, Zainab M. Maher, M. Mahdy, A. Metwally, M. Salah
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引用次数: 0

摘要

骨关节炎(OA)是一种表现为关节组织软骨退化和软骨下骨硬化的疾病。OA对承重关节的影响最为严重。根据一些研究,食用富含铜-白蛋白复合物(铜-白蛋白复合体)的食物有助于OA相关的关节退化和疼痛缓解。本研究的目的是确定口服铜-白蛋白复合物作为抗炎药如何影响大鼠膝骨关节炎(KOA)的发展。将50只成年白化大鼠分为三组:阴性对照组,未经治疗(n=10,无KOA诱导);阳性未处理对照(n=20,KOA诱导);和治疗组(n=20,给予铜-白蛋白复合物的KOA诱导)。根据临床症状的严重程度,将治疗组和未治疗组的关节炎患者平均分为轻度组和重度组(n=10)。碘乙酸单钠(MIA)作为关节内注射用于骨关节炎的诱导。实验开始一个月后对大鼠实施安乐死,并对关节进行组织病理学和免疫组织化学检查。结果表明,该治疗在降低KOA严重程度和改善受影响软骨的硫酸软骨素方面是有效的。总之,铜-白蛋白复合物改变了KOA大鼠膝关节软骨中硫酸软骨素的结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In Vivo Investigation of the Ameliorating Effect of Copper Albumin Complex on chondroitin sulfate in Monosodium iodoacetate -Induced Knee Osteoarthritis
Osteoarthritis (OA) is a condition that manifests as cartilage deterioration and subchondral bone sclerosis in the joint tissues. The weight-bearing joint is most severely impacted by OA. According to some research, consuming foods high in copper albumin complex (cu-albumin complex) can help with OA-related joint degeneration and pain relief. The current study's objective to determine how oral administration of the cu-albumin complex as an anti-inflammatory medication affected the development of rat knee osteoarthritis (KOA). Fifty adult albino rats were divided into three groups: negative control untreated (n= 10, no KOA induction); positive untreated control (n= 20, KOA induction); and treated group (n= 20, KOA induction with administration of cu-albumin complex). According to the severity of the clinical symptoms, treated and untreated arthritic groups were equally divided into mild and severe groups (n=10). Monosodium iodoacetate (MIA) was used as intra-articular injection for osteoarthritis induction. Rats were euthanized after a month of the beginning of the experiment, and the joints were examined histopathologically and immunohistochemically. It was indicated that the treatment was effective in reducing KOA severity and in improvement of chondroitin sulfate of the affected cartilages. In conclusion, the structure of the chondroitin sulphate in the knee joint cartilages of KOA-affected rats was modified by the cu-albumin complex.
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