如何选择合适的多囊卵巢综合征动物模型?

Amin Tamadon, Wei Hu, P. Cui, Tong Ma, Xiaoyu Tong, Feifei Zhang, Xin Li, Linus R. Shao, Yi Feng
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引用次数: 11

摘要

多囊卵巢综合征(PCOS)是一种病因不明的妇科代谢和内分泌紊乱。为了了解多囊卵巢综合征的病因或评估各种治疗药物,介绍了不同的动物模型。考虑到这一事实,很难开发出一种模拟该综合征所有方面的动物模型,但是,动物模型的生物学、解剖学和/或生物化学特征与人类多囊卵巢综合征表型的相似性可以增加其应用。本文对最近研究的动物模型进行了评估,并介绍了PCOS研究中用于不同研究目的的最佳模型。在2013年1月至2017年1月期间,确定了162项研究,这些研究应用了各种PCOS动物模型,包括啮齿动物、灵长类动物、反刍动物和鱼类。在这些模型之间,产前和青春期前的雄性大鼠模型以及产前雄性小鼠模型比其他模型进行了详细的研究。这些模型的主要特征与女性多囊卵巢综合征的比较表明,这三种模型与人类状况的相似性更高。此后,来曲唑模型可以被推荐用于PCOS的各个方面的研究。有趣的是,青春期后胰岛素和人绒毛膜促性腺激素大鼠模型的PCOS特征与女性PCOS的相似性相当大,这可以作为未来研究的良好选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How to choose the suitable animal model of polycystic ovary syndrome?
Polycystic ovary syndrome (PCOS) is a gynecological metabolic and endocrine disorder with uncertain etiology. To understand the etiology of PCOS or the evaluation of various therapeutic agents, different animal models have been introduced. Considering this fact that is difficult to develop an animal model that mimics all aspects of this syndrome, but, similarity of biological, anatomical, and/or biochemical features of animal model to the human PCOS phenotypes can increase its application. This review paper evaluates the recently researched animal models and introduced the best models for different research purposes in PCOS studies. During January 2013 to January 2017, 162 studies were identified which applied various kinds of animal models of PCOS including rodent, primate, ruminant and fish. Between these models, prenatal and pre-pubertal androgen rat models and then prenatal androgen mouse model have been studied in detail than others. The comparison of main features of these models with women PCOS demonstrates higher similarity of these three models to human conditions. Thereafter, letrozole models can be recommended for the investigation of various aspects of PCOS. Interestingly, similarity of PCOS features of post-pubertal insulin and human chorionic gonadotropin rat models with women PCOS were considerable which can make it as a good choice for future investigations.
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