艾灸CV8通过抑制p38 MAPK/NF-κβ信号通路减轻长期运动性疲劳大鼠心肌炎症反应

IF 0.2 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE
Yu-lei Liang, Zhi-fang Zhang, Tianyuan Lv, Zheng-xian Shen, Xin Wang, Shi-Jie Lv, Dong-yun Sun, Chaoyi Fang
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引用次数: 1

摘要

病理性心脏重构是导致运动员心源性猝死等心血管疾病的重要原因。遗憾的是,长期从事高强度耐力运动的人(尤其是专业运动员)对病理性心脏重构的成因和健康风险认识不充分,导致病理性心脏重构发展为不可逆损伤,严重影响运动事业和运动员的退役后生活。研究表明,长期反复高强度运动引起的心肌炎症是诱发病理性重构的先决条件,有效抑制炎症可阻断或逆转病理性重构的病理过程。本初步研究表明,在cv8时艾灸可抑制心肌p38丝裂原活化蛋白激酶/核因子-κβ (p38 MAPK/NF-κβ)信号通路,降低环氧化酶-2 (COX-2)、白细胞介素-6 (IL-6)、肿瘤坏死因子(TNF-α)的表达,显著改善长期反复高强度运动大鼠心肌形态和功能,有效预防病理性心脏重构。cev8穴位灸法为临床治疗病理性心脏重构提供了新的物理疗法和实验依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Moxibustion at CV 8 alleviates the myocardial inflammatory response in rats with long-term exercise-induced fatigue through inhibition of the p38 MAPK/NF-κβ signaling pathway
Pathological cardiac remodeling is an important cause of sudden cardiac death and other cardiovascular diseases in athletes. Unfortunately, people involved in long-term intense endurance exercise (especially professional athletes) do not fully understand the cause and health risks of pathological cardiac remodeling, resulting in pathological cardiac remodeling developing into irreversible damage, which seriously affects sports careers and the postretirement life of athletes. Studies have shown that myocardial inflammation caused by long-term and repeated high-intensity exercise is a prerequisite for inducing pathological remodeling and that effective inhibition of inflammation can block or reverse the pathological process of pathological remodeling. This preliminary study showed that moxibustion at CV 8 inhibited the p38 mitogen-activated protein kinases/nuclear factor-κβ (p38 MAPK/NF-κβ) signaling pathway in myocardium, reduced the expression of cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), and tumor necrosis factor(TNF-α), significantly improved myocardial morphology and function in rats under going long-term and repeated high-intensity exercise, and effectively prevented pathological cardiac remodeling. Moxibustion at CV 8 provides a new physical therapy and experimental basis for the treatment of pathological cardiac remodeling in clinical practice.
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来源期刊
Acupuncture & Electro-Therapeutics Research
Acupuncture & Electro-Therapeutics Research 医学-全科医学与补充医学
CiteScore
0.50
自引率
66.70%
发文量
9
审稿时长
>12 weeks
期刊介绍: The aim of the journal is to provide an international forum for the exchange of ideas and promotion of basic and clinical research in acupuncture, electro-therapeutics, and related fields. The journal was established in order to make acupuncture and electro-therapeutics a universally acceptable branch of medicine through multidisciplinary research based on scientific disciplines. The final goal is to provide a better understanding of both the beneficial and adverse effects of these treatments in order to supplement or improve existing methods of diagnosis, prognosis, treatment, and prevention of diseases in both Western and Oriental medicine.
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