化生和癌中食管祖细胞的去分化

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-10-21 DOI:10.1080/23723556.2021.1991758

Alizée Vercauteren Drubbel, Benjamin Beck

引用次数: 0

摘要

摘要Barrett综合征是一种鳞状柱状化生，增加了患食道腺癌的风险。最近，我们发现食管细胞可以在体内转分化为未分化的柱状细胞。在这里，我们讨论了这些细胞作为肠化生和/或食管腺癌宿主的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dedifferentiation of esophageal progenitors in metaplasia and cancer

ABSTRACT Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss about the potential of these cells to be a reservoir for intestinal metaplasia and/or esophageal adenocarcinoma.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.