Jean Guillon, Maria de Fatima Pereira-Rosenfeld, Noël Pinaud, Thierry Besson, V. Thiéry, Laurent Picot, Mathieu Marchivie
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引用次数: 3595
摘要
建立了具有抗A2058黑色素瘤细胞增殖潜力的6,7-二氢-5a,7a,13,14-四氮杂-五苯-5,8-二酮的x射线晶体结构。晶胞参数为a = 24.879(3) a, b = 6.868(2) a, c = 26.068(4A)， α = 90， β = 110.49(2)， γ = 90, V = 4172.4(15)A3, Z = 12。晶体结构细化至最终值R1 = 0.1353, wR2 = 0.1936。x射线晶体结构分析显示，每个分子都具有分子间的CArom。-H···O氢键形成三聚体。
Crystal Structure of 6,7-Dihydro-5a,7a,13,14-tetraaza-pentaphene-5,8-dione
The X-ray crystal structure of 6,7-dihydro-5a,7a,13,14-tetraaza-pentaphene-5,8-dione, a potential antiproliferative agent on A2058 melanoma cells, was established. It crystallizes in the monoclinic space group P21/c with cell parameters a = 24.879(3)A, b = 6.868(2)A, c = 26.068(4A, α = 90, β = 110.49(2), γ = 90, V = 4172.4(15)A3 and Z = 12. The crystal structure was refined to final values of R1 = 0.1353 and wR2 = 0.1936. An X-ray crystal structure analysis revealed that each molecule features intermolecular CArom.–H···O hydrogen bonds to form trimers.
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