重症肌无力相关抗体的研究进展

中国小儿急救医学 Pub Date : 2020-02-20 DOI:10.3760/CMA.J.ISSN.1673-4912.2020.02.015

T. Ma

{"title":"重症肌无力相关抗体的研究进展","authors":"T. Ma","doi":"10.3760/CMA.J.ISSN.1673-4912.2020.02.015","DOIUrl":null,"url":null,"abstract":"As an autoimmune disease involving the neuromuscular junction, the pathogenesis of myasthenia gravis(MG) is closely related to autoimmune antibodies.Regarding related antibodies, acetylcholine receptor antibody(AChR-Ab) is the most studied and clear.In recent years, researchers have began to study antibodies other than AChR-Ab due to the presence of AChR-Ab-negative MG patients, such as muscle-specific tyrosine kinase antibodies, low-density lipoprotein 4 antibodies, and explore the corresponding treatment options.This article reviewed the research progress of MG related antibodies, and provided clinical evidence and reference for the future treatment of this disease. \n \n \nKey words: \nAntibody; Myasthenia gravis; Autoimmune disease; Thyroid","PeriodicalId":68901,"journal":{"name":"中国小儿急救医学","volume":"27 1","pages":"144-148"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advances in the study of antibodies associated with myasthenia gravis\",\"authors\":\"T. Ma\",\"doi\":\"10.3760/CMA.J.ISSN.1673-4912.2020.02.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"As an autoimmune disease involving the neuromuscular junction, the pathogenesis of myasthenia gravis(MG) is closely related to autoimmune antibodies.Regarding related antibodies, acetylcholine receptor antibody(AChR-Ab) is the most studied and clear.In recent years, researchers have began to study antibodies other than AChR-Ab due to the presence of AChR-Ab-negative MG patients, such as muscle-specific tyrosine kinase antibodies, low-density lipoprotein 4 antibodies, and explore the corresponding treatment options.This article reviewed the research progress of MG related antibodies, and provided clinical evidence and reference for the future treatment of this disease. \\n \\n \\nKey words: \\nAntibody; Myasthenia gravis; Autoimmune disease; Thyroid\",\"PeriodicalId\":68901,\"journal\":{\"name\":\"中国小儿急救医学\",\"volume\":\"27 1\",\"pages\":\"144-148\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国小儿急救医学\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-4912.2020.02.015\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国小儿急救医学","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4912.2020.02.015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

重症肌无力作为一种涉及神经肌肉接头的自身免疫性疾病，其发病机制与自身免疫抗体密切相关。关于相关抗体，乙酰胆碱受体抗体（AChR-Ab）是研究最多和最清楚的。近年来，由于存在AChR-Ab阴性MG患者，研究人员开始研究AChR-Ab以外的抗体，如肌肉特异性酪氨酸激酶抗体、低密度脂蛋白4抗体，并探索相应的治疗方案。本文综述了MG相关抗体的研究进展，为今后该病的治疗提供了临床依据和参考。关键词：抗体；重症肌无力；自身免疫性疾病；甲状腺

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Advances in the study of antibodies associated with myasthenia gravis

As an autoimmune disease involving the neuromuscular junction, the pathogenesis of myasthenia gravis(MG) is closely related to autoimmune antibodies.Regarding related antibodies, acetylcholine receptor antibody(AChR-Ab) is the most studied and clear.In recent years, researchers have began to study antibodies other than AChR-Ab due to the presence of AChR-Ab-negative MG patients, such as muscle-specific tyrosine kinase antibodies, low-density lipoprotein 4 antibodies, and explore the corresponding treatment options.This article reviewed the research progress of MG related antibodies, and provided clinical evidence and reference for the future treatment of this disease. Key words: Antibody; Myasthenia gravis; Autoimmune disease; Thyroid

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中国小儿急救医学

自引率

0.00%

发文量

6226

期刊介绍： Chinese Journal of Neurology was established in 1955, the predecessor of which is Chinese Journal of Neurology and Psychiatry. Chinese Journal of Neurology and Psychiatry has been indexed by MEDLINE until 1996, when it was divided into two journals, Chinese Journal of Neurology, and Chinese Journal of Psychiatry. Chinese Journal of Neurology is now indexed by EM, SCOPUS, AJ, WPRIM, CNKI, Wanfang Data, CSCD, etc. The impact factor of the journal is 2.755 in 2017, ranking the first among all neurological and psychological journals in China and among all the 142 medical journals published by the Chinese Medical Association. The journal is available both in print and online.